Lee Shin Yup, Choi Jin Eun, Jeon Hyo-Sung, Choi Yi-Young, Lee Won Kee, Lee Eung Bae, Lee Hyun Cheol, Kang Hyo-Gyoung, Yoo Seung Soo, Lee Jaehee, Cha Seung Ick, Kim Chang Ho, Lee Myung Hoon, Kim Young Tae, Jheon Sanghoon, Park Jae Yong
Departments of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Lung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Departments of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Lung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
PLoS One. 2015 Oct 13;10(10):e0140216. doi: 10.1371/journal.pone.0140216. eCollection 2015.
This study was conducted to investigate whether a panel of eight genetic polymorphisms can predict the prognosis of patients with early stage non-small cell lung cancer (NSCLC) after surgical resection.
We selected eight single nucleotide polymorphisms (SNPs) which have been associated with the prognosis of lung cancer patients after surgery in our previous studies. A total of 814 patients with early stage NSCLC who underwent curative surgical resection were enrolled. The association of the eight SNPs with overall survival (OS) and disease-free survival (DFS) was analyzed.
The eight SNPs (CD3EAP rs967591, TNFRSF10B rs1047266, AKT1 rs3803300, C3 rs2287845, HOMER2 rs1256428, GNB2L1 rs3756585, ADAMTSL3 rs11259927, and CD3D rs3181259) were significantly associated with OS and/or DFS. Combining those eight SNPs, we designed a prognostic index to predict the prognosis of patients. According to relative risk of death, a score value was assigned to each genotype of the SNPs. A worse prognosis corresponded to a higher score value, and the sum of score values of eight SNPs defined the prognostic index of a patient. When we categorized the patients into two groups based on the prognostic index, high risk group was significantly associated with worse OS and DFS compared to low risk group (aHR for OS = 2.21, 95% CI = 1.69-2.88, P = 8.0 x 10-9, and aHR for DFS = 1.58, 95% CI = 1.29-1.94, P = 1.0 x 10-5).
Prognostic index using eight genetic polymorphisms may be useful for the prognostication of patients with surgically resected NSCLC.
本研究旨在调查一组8个基因多态性是否能够预测早期非小细胞肺癌（NSCLC）患者手术切除后的预后。
我们选择了8个单核苷酸多态性（SNP），这些SNP在我们之前的研究中已被证明与肺癌患者术后的预后相关。总共纳入了814例行根治性手术切除的早期NSCLC患者。分析了这8个SNP与总生存期（OS）和无病生存期（DFS）的相关性。
这8个SNP（CD3EAP rs967591、TNFRSF10B rs1047266、AKT1 rs3803300、C3 rs2287845、HOMER2 rs1256428、GNB2L1 rs3756585、ADAMTSL3 rs11259927和CD3D rs3181259）与OS和/或DFS显著相关。结合这8个SNP，我们设计了一个预后指数来预测患者的预后。根据死亡相对风险，为每个SNP的基因型赋予一个分值。预后越差，分值越高，8个SNP的分值总和定义为患者的预后指数。当我们根据预后指数将患者分为两组时，与低风险组相比，高风险组的OS和DFS明显更差（OS的aHR = 2.21，95%CI = 1.69 - 2.88，P = 8.0×10⁻⁹；DFS的aHR = 1.58，95%CI = 1.29 - 1.94，P = 1.0×10⁻⁵）。
使用8个基因多态性的预后指数可能有助于预测手术切除的NSCLC患者的预后。
Zotero 插件