N-羟基-2-乙酰氨基芴在大鼠和小鼠离体肝细胞核中的体外诱变激活及共价结合机制 - Suppr

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Mechanism of in vitro mutagenic activation and covalent binding of N-hydroxy-2-acetylaminofluorene in isolated liver cell nuclei from rat and mouse.

作者信息

Sakai S, Reinhold C E, Wirth P J, Thorgeirsson S S

出版信息

Cancer Res. 1978 Jul;38(7):2058-67.

PMID:26463

Abstract

摘要

相似文献

Mechanism of in vitro mutagenic activation and covalent binding of N-hydroxy-2-acetylaminofluorene in isolated liver cell nuclei from rat and mouse.N-羟基-2-乙酰氨基芴在大鼠和小鼠离体肝细胞核中的体外诱变激活及共价结合机制

Cancer Res. 1978 Jul;38(7):2058-67.

Mutagenic activation of N-hydroxy-2-acetylaminofluorene in the Salmonella test system: the role of deacetylation by liver and kidney fractions from mouse and rat.N-羟基-2-乙酰氨基芴在沙门氏菌测试系统中的诱变激活：小鼠和大鼠肝脏及肾脏组分脱乙酰作用的影响

Mol Pharmacol. 1978 Jul;14(4):682-92.

In vitro metabolism and mutagenic activation of 2-acetylaminofluorene by subcellular liver fractions from Cotton rats.

Cancer Res. 1978 Aug;38(8):2501-7.

Mutagenic activation of N-hydroxy-2-acetylaminofluorene by developing epithelial cells of rat small intestine and effects of antioxidants.

J Natl Cancer Inst. 1979 Dec;63(6):1405-9.

Role of arylhydroxamic acid acyltransferase in the mutagenicity of N-hydroxy-N-2-fluorenylacetamide in Salmonella typhimurium.芳基异羟肟酸酰基转移酶在N-羟基-N-2-芴基乙酰胺对鼠伤寒沙门氏菌致突变性中的作用。

Cancer Res. 1978 Mar;38(3):613-8.

Metabolic activation of 2-aminofluorene, 2-acetylaminofluorene and N-hydroxy-acetylaminofluorene to bacterial mutagens with mussel (Mytilus galloprovincialis) and carp (Cyprinus carpio) subcellular preparations.利用贻贝（加利福尼亚贻贝）和鲤鱼（鲤）亚细胞制剂将2-氨基芴、2-乙酰氨基芴和N-羟基-乙酰氨基芴代谢活化为细菌诱变剂。

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;88(1):171-7. doi: 10.1016/0742-8413(87)90063-6.

Activation of N-acetoxy- and N-hydroxy-2-acetylaminofluorene to mutagenic and cytotoxic metabolites by V79 Chinese hamster cells.V79中国仓鼠细胞将N-乙酰氧基-和N-羟基-2-乙酰氨基芴激活为致突变和细胞毒性代谢物。

Mutat Res. 1985 Apr;149(2):265-9.

The relationship of 2-acetamidofluorene mutagenicity in plate tests with its in vivo liver cell component distribution and its carcinogenic potential.平板试验中2-乙酰氨基芴的诱变性与其体内肝细胞成分分布及其致癌潜力的关系。

Mutat Res. 1975 Dec;30(3):305-15.

N'-hydroxy-2-aminofluorene: the principal mutagen produced from N-hydroxy-2-acetylaminofluorene by a mammalian supernatant enzyme preparation.

Cancer Lett. 1976 May;1(5):269-74. doi: 10.1016/s0304-3835(75)97640-5.

Species difference in liver microsomal and cytosolic enzymes involved in mutagenic activation of N-hydroxy-N-2-fluorenylacetamide.参与N-羟基-N-2-芴基乙酰胺诱变激活的肝脏微粒体和胞质酶的物种差异。

J Natl Cancer Inst. 1981 Sep;67(3):549-55.

引用本文的文献

Aminofluorene-DNA adduct formation in Salmonella typhimurium exposed to the carcinogen N-hydroxy-2-acetylaminofluorene.暴露于致癌物N-羟基-2-乙酰氨基芴的鼠伤寒沙门氏菌中氨基芴-DNA加合物的形成。

Proc Natl Acad Sci U S A. 1982 Sep;79(17):5175-8. doi: 10.1073/pnas.79.17.5175.

Interaction of DNA methyltransferase with aminofluorene and N-acetylaminofluorene modified poly(dC-dG).DNA甲基转移酶与氨基芴及N - 乙酰氨基芴修饰的聚（dC - dG）的相互作用

Nucleic Acids Res. 1984 Apr 11;12(7):3357-72. doi: 10.1093/nar/12.7.3357.

Genotoxicity of N-acetylarylamines in the salmonella/hepatocyte system.N-乙酰芳胺在沙门氏菌/肝细胞系统中的遗传毒性。

Environ Health Perspect. 1983 Mar;49:141-5. doi: 10.1289/ehp.8349141.

Effects of vitamin A on the metabolism and mutagenicity of 2AAF in vitro and on the covalent binding to rat liver DNA/RNA in vivo.维生素A对2-乙酰氨基芴在体外的代谢和致突变性以及在体内与大鼠肝脏DNA/RNA共价结合的影响。

Arch Toxicol. 1985 Aug;57(3):178-83. doi: 10.1007/BF00290884.

A comparison of the inhibition of deacetylase in primary cultures of rat and human hepatocytes effecting metabolism and DNA-binding of 2-acetylaminofluorene.大鼠和人原代肝细胞中脱乙酰酶抑制作用对2-乙酰氨基芴代谢及DNA结合影响的比较

Cell Biol Toxicol. 1990 Jul;6(3):269-84. doi: 10.1007/BF02443802.

Alkaline stability of guanosine and some of its derivatives modified by the carcinogen N-acetoxyacetylaminofluorene.鸟苷及其一些被致癌物N - 乙酰氧基乙酰氨基芴修饰的衍生物的碱性稳定性。

Nucleic Acids Res. 1979 Dec 20;7(8):2347-56. doi: 10.1093/nar/7.8.2347.

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