N-羟基-2-乙酰氨基芴在沙门氏菌测试系统中的诱变激活：小鼠和大鼠肝脏及肾脏组分脱乙酰作用的影响 - Suppr

Suppr

超能文献

Mutagenic activation of N-hydroxy-2-acetylaminofluorene in the Salmonella test system: the role of deacetylation by liver and kidney fractions from mouse and rat.

作者信息

Schut H A, Wirth P J, Thorgeirsson S S

出版信息

Mol Pharmacol. 1978 Jul;14(4):682-92.

PMID:683178

Abstract

摘要

相似文献

Mutagenic activation of N-hydroxy-2-acetylaminofluorene in the Salmonella test system: the role of deacetylation by liver and kidney fractions from mouse and rat.N-羟基-2-乙酰氨基芴在沙门氏菌测试系统中的诱变激活：小鼠和大鼠肝脏及肾脏组分脱乙酰作用的影响

Mol Pharmacol. 1978 Jul;14(4):682-92.

Mechanism of in vitro mutagenic activation and covalent binding of N-hydroxy-2-acetylaminofluorene in isolated liver cell nuclei from rat and mouse.N-羟基-2-乙酰氨基芴在大鼠和小鼠离体肝细胞核中的体外诱变激活及共价结合机制

Cancer Res. 1978 Jul;38(7):2058-67.

Studies on the mutagenicity of N-hydroxy-2-acetylaminofluorene in the Ames-Salmonella mutagenesis test system.在埃姆斯-沙门氏菌诱变试验系统中对N-羟基-2-乙酰氨基芴致突变性的研究。

Biochem Pharmacol. 1978;27(20):2399-408. doi: 10.1016/0006-2952(78)90351-9.

Mechanism of N-hydroxyacetylarylamine mutagenicity in the Salmonella test system: metabolic activation of N-hydroxyphenacetin by liver and kidney fractions from rat, mouse, hamster, and man.

Mol Pharmacol. 1980 Jul;18(1):117-27.

In vitro metabolism and mutagenic activation of 2-acetylaminofluorene by subcellular liver fractions from Cotton rats.

Cancer Res. 1978 Aug;38(8):2501-7.

Mutagenic activation of N-hydroxy-2-acetylaminofluorene by developing epithelial cells of rat small intestine and effects of antioxidants.

J Natl Cancer Inst. 1979 Dec;63(6):1405-9.

Species difference in liver microsomal and cytosolic enzymes involved in mutagenic activation of N-hydroxy-N-2-fluorenylacetamide.参与N-羟基-N-2-芴基乙酰胺诱变激活的肝脏微粒体和胞质酶的物种差异。

J Natl Cancer Inst. 1981 Sep;67(3):549-55.

Mechanism of N-hydroxy-2-acetylaminofluorene mutagenicity in the Salmonella test system. Role of N-O acyltransferase and sulfotransferase from rat liver.

Mol Pharmacol. 1981 Mar;19(2):337-44.

Role of arylhydroxamic acid acyltransferase in the mutagenicity of N-hydroxy-N-2-fluorenylacetamide in Salmonella typhimurium.

Cancer Res. 1978 Mar;38(3):613-8.

The role of acetylator genotype on hepatic and extrahepatic acetylation, deacetylation, and sulfation of 2-aminofluorene, 2-acetylaminofluorene, and N-hydroxy-2-acetylaminofluorene in the inbred hamster.乙酰化酶基因型在近交系仓鼠中对2-氨基芴、2-乙酰氨基芴和N-羟基-2-乙酰氨基芴的肝内和肝外乙酰化、去乙酰化及硫酸化作用中的角色。

Drug Metab Dispos. 1986 Sep-Oct;14(5):566-73.

引用本文的文献

Metabolic activation of 2-acetylaminofluorene by isolated rat liver cells. Involvement of different metabolites causing DNA-repair and bacterial mutagenesis.离体大鼠肝细胞对2-乙酰氨基芴的代谢活化。不同代谢产物与DNA修复及细菌诱变的关联。

Arch Toxicol. 1980 May;45(1):53-9. doi: 10.1007/BF00303295.

Aminofluorene-DNA adduct formation in Salmonella typhimurium exposed to the carcinogen N-hydroxy-2-acetylaminofluorene.暴露于致癌物N-羟基-2-乙酰氨基芴的鼠伤寒沙门氏菌中氨基芴-DNA加合物的形成。

Proc Natl Acad Sci U S A. 1982 Sep;79(17):5175-8. doi: 10.1073/pnas.79.17.5175.

Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.致癌物N-羟基-2-乙酰氨基芴在体内与大鼠肝脏DNA重复序列的非随机结合。

Proc Natl Acad Sci U S A. 1984 Nov;81(22):6943-7. doi: 10.1073/pnas.81.22.6943.

Modulation of genotoxic and cytotoxic effects of aromatic amines in monolayers of rat hepatocytes.大鼠肝细胞单层中芳香胺遗传毒性和细胞毒性作用的调节

Cell Biol Toxicol. 1984 Oct;1(1):95-110. doi: 10.1007/BF00125568.

Genotoxicity of N-acetylarylamines in the salmonella/hepatocyte system.N-乙酰芳胺在沙门氏菌/肝细胞系统中的遗传毒性。

Environ Health Perspect. 1983 Mar;49:141-5. doi: 10.1289/ehp.8349141.

Effect of acetylated and deacetylated 2-aminofluorene adducts on in vitro DNA synthesis.

Proc Natl Acad Sci U S A. 1982 Dec;79(23):7166-70. doi: 10.1073/pnas.79.23.7166.

Gas chromatography-mass spectrometry analysis of tert.-butyldimethylsilyl derivatives of 2-acetylaminofluorene and metabolites in isolated rat hepatocytes.

Cell Biol Toxicol. 1987 Sep;3(3):327-40. doi: 10.1007/BF00117869.

V79 Chinese hamster cells deacetylate trans-N-acetoxy-4-acetylaminostilbene and trans-N-hydroxy-4-acetylaminostilbene to mutagenic and cytotoxic metabolites.V79中国仓鼠细胞将反式-N-乙酰氧基-4-乙酰氨基芪和反式-N-羟基-4-乙酰氨基芪脱乙酰化为具有致突变性和细胞毒性的代谢产物。

Cell Biol Toxicol. 1986 Jun;2(2):213-21. doi: 10.1007/BF00122690.

A comparison of the inhibition of deacetylase in primary cultures of rat and human hepatocytes effecting metabolism and DNA-binding of 2-acetylaminofluorene.大鼠和人原代肝细胞中脱乙酰酶抑制作用对2-乙酰氨基芴代谢及DNA结合影响的比较

Cell Biol Toxicol. 1990 Jul;6(3):269-84. doi: 10.1007/BF02443802.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验