Dipartimento di Scienze Veterinarie e Sanità Pubblica, Università degli Studi di Milano, Milano, Italy.
Dipartimento di Scienze Veterinarie, Università degli Studi di Torino, Torino, Italy.
Vet Comp Oncol. 2017 Jun;15(2):366-373. doi: 10.1111/vco.12172. Epub 2015 Oct 14.
Richter's syndrome (RS) is the development of an aggressive lymphoma in patients with chronic lymphocytic leukaemia (CLL). In humans, RS occurs in 2-20% of CLL, which transform into diffuse large B-cell lymphoma but reports in dogs are scarce. This study retrospectively describes eight dogs with CLL progressing into RS. A database including 153 dogs with CLL (93T CD8+ and 55 B-CLL) was interrogated and RS was demonstrated in eight cases (representing 5.2% of total CLL): two with T-cell (2.2% of T CLL) and six with a B-cell immunophenotype (10.9% of B-CLL). When RS occurred, lymphocytes were decreased compared to CLL. Five dogs had anaemia and two dogs thrombocytopenia. Frequent clinical signs included lymph node swelling, coughing, vomiting, neurological signs and weight loss. Independently from the therapy, RS was associated with a short survival (median 41 days). RS should be considered as an unfavourable evolution in canine CLL.
里希特氏综合征（RS）是慢性淋巴细胞白血病（CLL）患者中侵袭性淋巴瘤的发展。在人类中，RS 发生在 2-20%的 CLL 中，转化为弥漫性大 B 细胞淋巴瘤，但在狗中的报道很少。本研究回顾性描述了 8 例 CLL 进展为 RS 的犬病例。对包括 153 例 CLL 犬（93T CD8+和 55 例 B-CLL）的数据库进行了查询，结果显示 8 例（占总 CLL 的 5.2%）发生了 RS：2 例为 T 细胞（2.2%的 T-CLL），6 例为 B 细胞免疫表型（10.9%的 B-CLL）。当发生 RS 时，与 CLL 相比，淋巴细胞减少。5 只犬出现贫血，2 只犬出现血小板减少。常见的临床症状包括淋巴结肿大、咳嗽、呕吐、神经症状和体重减轻。无论治疗如何，RS 均与较短的生存时间相关（中位 41 天）。RS 应被视为犬 CLL 的不良进展。
