Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460.

作者信息

Tatsuda Daisuke, Amemiya Masahide, Sawa Ryuichi, Sumiyoshi Kengo, Watanabe Takumi, Momose Isao, Kawada Manabu, Nomoto Akio, Shibasaki Masakatsu

机构信息

Institute of Microbial Chemistry (BIKAKEN), Shizuoka, Japan.

Institute of Microbial Chemistry (BIKAKEN), Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 2016 Mar;69(3):176-8. doi: 10.1038/ja.2015.102. Epub 2015 Oct 14.

DOI:10.1038/ja.2015.102

PMID:26464010

Abstract

摘要

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Tumour suppression by p53: a role for the DNA damage response?p53介导的肿瘤抑制作用：DNA损伤反应起作用吗？

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.通过MDM2小分子拮抗剂在体内激活p53通路。

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