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拟青霉醌A、B、C、D、E和F：肉座菌产生的新型强效蛋白酪氨酸激酶抑制剂。II. 表征与结构测定。

Paeciloquinones A, B, C, D, E and F: new potent inhibitors of protein tyrosine kinase produced by Paecilomyces carneus. II. Characterization and structure determination.

作者信息

Fredenhagen A, Hug P, Sauter H, Peter H H

机构信息

Pharmaceutical Research Department, Ciba-Geigy Ltd., Basel, Switzerland.

出版信息

J Antibiot (Tokyo). 1995 Mar;48(3):199-204. doi: 10.7164/antibiotics.48.199.

DOI:10.7164/antibiotics.48.199
PMID:7730152
Abstract

Paeciloquinones A to F and versiconol have been isolated as inhibitors of protein tyrosine kinases from the culture broth of the fungus Paecilomyces carneus P-177. The structures of the new anthraquinones were determined by spectroscopic methods, mainly 1H NMR and 13C NMR. The substitution pattern was established by investigation of the respective methylated derivatives.

摘要

从肉色拟青霉P-177的培养液中分离得到了青霉醌A至F以及Versiconol，它们是蛋白酪氨酸激酶的抑制剂。通过光谱方法，主要是1H NMR和13C NMR确定了新蒽醌类化合物的结构。通过对各自甲基化衍生物的研究确定了取代模式。

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