0.1%己脒定与0.12%葡萄糖酸氯己定在消除义齿上白色念珠菌定植方面的效果比较：一项随机临床体内研究
Effectiveness of Hexetidine 0.1% Compared to Chlorhexidine Digluconate 0.12% in Eliminating Candida Albicans Colonizing Dentures: A Randomized Clinical In Vivo Study.
作者信息
Aoun Georges, Saadeh Maria, Berberi Antoine
机构信息
Assistant Professor, Department of Oral Pathology and Diagnosis, School of Dentistry, Lebanese University, Beirut, Lebanon.
Chief of Clinical Services, Department of Orthodontics, School of Dentistry, Lebanese University, Beirut, Lebanon ; Clinical Associate, Department of Orthodontics and Dentofacial Orthopedics, American University of Beirut, Lebanon.
出版信息
J Int Oral Health. 2015 Aug;7(8):5-8.
BACKGROUND
Denture hygiene is an important factor in the prevention and treatment of denture stomatitis (DS). This study aimed to evaluate the efficacy of two different mouthwashes (chlorhexidine digluconate 0.12% and hexetidine 0.1%) in eliminating Candida albicans on dentures.
MATERIALS AND METHODS
A total of 60 denture wearers (20 men, 40 women; age range 40-80 years) with clinical evidence of DS were randomly divided into 2 test groups and 1 control group. The dentures of each test group were treated by immersion in one of the two mouthwashes while those of the control group were immersed in distilled water. Swab samples from the palatal surfaces of the upper dentures were collected before and after of cleaner use and examined mycologically.
RESULTS
Reduction in the number of colony-forming units of Candida albicans after immersion of the dentures with chlorhexidine digluconate 0.12% was significantly greater than that of the group using hexetidine 0.1% and those of the control group.
CONCLUSION
Hexetidine 0.1% solution tested for the first time as a product of disinfection of the acrylic dentures showed average results after immersion of 8 night hours for 4 days and was less effective than chlorhexidine digluconate 0.12%.
背景
义齿卫生是预防和治疗义齿性口炎（DS）的一个重要因素。本研究旨在评估两种不同漱口水（0.12%葡萄糖酸氯己定和0.1%己脒定）在消除义齿上白色念珠菌方面的疗效。
材料与方法
共有60名有DS临床证据的义齿佩戴者（20名男性，40名女性；年龄范围40 - 80岁）被随机分为2个试验组和1个对照组。每个试验组的义齿通过浸泡在两种漱口水之一中进行处理，而对照组的义齿浸泡在蒸馏水中。在上颌义齿的腭面使用清洁剂前后采集拭子样本，并进行真菌学检查。
结果
用0.12%葡萄糖酸氯己定浸泡义齿后，白色念珠菌的菌落形成单位数量减少显著大于使用0.1%己脒定的组和对照组。
结论
0.1%己脒定溶液作为一种丙烯酸义齿消毒产品首次进行测试，在浸泡8个夜间小时共4天后显示出一般的效果，且不如0.12%葡萄糖酸氯己定有效。
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