Wang Yin Qian, Fan Tao, Zhao Xin Gang, Liang Cong, Qi Xue Ling, Li Jian Yi
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University Beijing, P. R. China.
Department of Pathology, Sanbo Brain Hospital, Capital Medical University Beijing, P. R. China.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9712-7. eCollection 2015.
Pituitary carcinomas are rare malignant neoplasms with diagnostic and management challenges. Patients with pituitary carcinomas have extremely poor outcomes. In this report, the authors describe two cases of pituitary carcinomas with intraspinal metastasis (Case 1: 42-year-old man with a history of pituitary adenoma 16 years ago developed an intraspinal lesion at C4-C5; Case 2: 26-year-old women with a history of growth hormone-producing pituitary adenoma 9 years ago developed intraspinal lesion in the sacral canal). Both patients underwent spine surgery. The intraspinal lesions were confirmed as metastatic pituitary carcinomas based on the histomorphology and immunohistochemical stains. The authors reviewed the literature for the diagnosis, treatment, and prognosis of intraspinal metastasis from pituitary carcinomas.
垂体癌是罕见的恶性肿瘤，在诊断和治疗方面存在挑战。垂体癌患者的预后极差。在本报告中，作者描述了两例发生脊柱转移的垂体癌病例（病例1：一名42岁男性，16年前有垂体腺瘤病史，在C4 - C5水平出现脊柱内病变；病例2：一名26岁女性，9年前有分泌生长激素的垂体腺瘤病史，在骶管出现脊柱内病变）。两名患者均接受了脊柱手术。根据组织形态学和免疫组化染色，脊柱内病变被确诊为转移性垂体癌。作者回顾了有关垂体癌脊柱转移的诊断、治疗和预后的文献。
