从加夫库尼湿地（伊朗）分离出的海洋单胞菌属菌株GK1的全基因组分析表明存在毒力和致病性相关基因。
Genome-Wide Analysis of Oceanimonas sp. GK1 Isolated from Gavkhouni Wetland (Iran) Demonstrates Presence of Genes for Virulence and Pathogenicity.
作者信息
Parsa Yeganeh Laleh, Azarbaijani Reza, Mousavi Hossein, Shahzadeh Fazeli Seyed Abolhassan, Amoozgar Mohammad Ali, Salekdeh Ghasem Hosseini
机构信息
Molecular Bank, Iranian Biological Resource Center (IBRC), ACECR, Tehran, Iran.
Molecular Bank, Iranian Biological Resource Center (IBRC), ACECR, Tehran, Iran ; Faculty of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran.
出版信息
Cell J. 2015 Fall;17(3):451-60. doi: 10.22074/cellj.2015.6. Epub 2015 Oct 7.
OBJECTIVE
The bacterium Oceanimonas sp. (O. sp.) GK1 is a member of the Aeromonadaceae family and its genome represents several virulence genes involved in fish and human pathogenicity. In this original research study we aimed to identify and characterize the putative virulence factors and pathogenicity of this halotolerant marine bacterium using genome wide analysis.
MATERIALS AND METHODS
The genome data of O. sp. GK1 was obtained from NCBI. Comparative genomic study was done using MetaCyc database.
RESULTS
Whole genome data analysis of the O. sp. GK1 revealed that the bacterium possesses some important virulence genes (e.g. ZOT, RTX toxin, thermostable hemolysin, lateral flagella and type IV pili) which have been implicated in adhesion and biofilm formation and infection in some other pathogenic bacteria.
CONCLUSION
This is the first report of the putative pathogenicity of O. sp.GK1. The genome wide analysis of the bacterium demonstrates the presence of virulence genes causing infectious diseases in many warmand cold-blooded animals.
目的
海洋单胞菌属（Oceanimonas sp.）GK1 细菌是气单胞菌科的成员，其基因组包含多个与鱼类和人类致病性相关的毒力基因。在这项原创性研究中，我们旨在通过全基因组分析来鉴定和表征这种耐盐海洋细菌的假定毒力因子和致病性。
材料与方法
海洋单胞菌属 GK1 的基因组数据来自美国国立生物技术信息中心（NCBI）。使用 MetaCyc 数据库进行比较基因组研究。
结果
海洋单胞菌属 GK1 的全基因组数据分析表明，该细菌拥有一些重要的毒力基因（如 ZOT、RTX 毒素、耐热溶血素、侧生鞭毛和 IV 型菌毛），这些基因在其他一些病原菌的黏附、生物膜形成和感染中发挥作用。
结论
这是关于海洋单胞菌属 GK1 假定致病性的首次报道。对该细菌的全基因组分析表明存在可导致许多温血和冷血动物感染性疾病的毒力基因。
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