Gudala Kapil, Kanukula Raju, Bansal Dipika
Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab 160062, India.
Int J Chronic Dis. 2015;2015:697404. doi: 10.1155/2015/697404. Epub 2015 Feb 3.
Aim. To pool the data currently available to determine the association between calcium channel blockers (CCBs) and risk of Parkinson's disease (PD). Methods. Literature search in PubMed, EBSCO, and Cochrane library was undertaken through March 2014, looking for observational studies evaluating the association between CCBs use and PD. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model. Subgroup analyses, sensitivity Analysis, and cumulative meta-analysis were also performed. Results. Six studies were included in our meta-analysis according to the selection criteria, including three cohort studies and three case-control studies involving 27,67,990 subjects including 11,941 PD cases. We found CCBs use was associated with significant decreased risk of PD, compared with not using CCBs (random effects model pooled RR, 0.81 (95% CI, 0.69-0.95)); a significant heterogeneity was found between studies (P = 0.031; I (2) 54.6%). Both the classes of CCB, that is, dihydropyridine calcium channel blockers (DiCCB) (0.80 (95% CI, 0.65-0.98) P = 0.032) and non-DiCCB (0.70 (95% CI, 0.53-0.92) P = 0.013), were found to be reducing the risk of PD. Conclusion. In our analysis, we found that CCBs use was associated with a Significantly decreased risk of PD compared with non-CCB use.
目的。汇总当前可用数据，以确定钙通道阻滞剂（CCB）与帕金森病（PD）风险之间的关联。方法。截至2014年3月，在PubMed、EBSCO和Cochrane图书馆进行文献检索，寻找评估CCB使用与PD之间关联的观察性研究。使用随机效应模型计算合并相对风险（RR）估计值和95%置信区间（CI）。还进行了亚组分析、敏感性分析和累积荟萃分析。结果。根据选择标准，六项研究纳入我们的荟萃分析，包括三项队列研究和三项病例对照研究，涉及2767990名受试者，其中包括11941例PD病例。我们发现，与未使用CCB相比，使用CCB与PD风险显著降低相关（随机效应模型合并RR，0.81（95%CI，0.69 - 0.95））；研究之间存在显著异质性（P = 0.031；I² 54.6%）。发现CCB的两类，即二氢吡啶类钙通道阻滞剂（DiCCB）（0.80（95%CI，0.65 - 0.98）P = 0.032）和非DiCCB（0.70（95%CI，0.53 - 0.92）P = 0.013），均能降低PD风险。结论。在我们的分析中，我们发现与未使用CCB相比，使用CCB与PD风险显著降低相关。
