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帕金森病模型小鼠中上调的与 DNA 损伤相关的生物标志物。

Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice.

机构信息

Department of Neurology, Renmin Hospital of the Wuhan University, Wuhan, China.

Departments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, Johnson City, TN, USA.

出版信息

ASN Neuro. 2023 Jan-Dec;15:17590914231152099. doi: 10.1177/17590914231152099.

DOI:10.1177/17590914231152099
PMID:36683340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9880594/
Abstract

The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.

摘要

本研究检测了 VMAT2 Lo PD 模型小鼠中 DNA 损伤标志物的表达。结果表明，这些 DNA 损伤标志物在 18 月龄和 23 月龄模型小鼠的大脑区域中显著增加，表明氧化应激诱导的 DNA 损伤是该小鼠模型的一个重要病理特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/f92847a2771c/10.1177_17590914231152099-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/f0dc3f4bdf0b/10.1177_17590914231152099-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/fed27cfe6b9e/10.1177_17590914231152099-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/9d2d5a6fa64a/10.1177_17590914231152099-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/0278d8e1f562/10.1177_17590914231152099-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/b00f6eced9e6/10.1177_17590914231152099-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/521ae4e2cabb/10.1177_17590914231152099-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/79f9dce17038/10.1177_17590914231152099-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/56b5bb8b94b4/10.1177_17590914231152099-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/b8f2ade479b5/10.1177_17590914231152099-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/65aaa5220aff/10.1177_17590914231152099-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/f92847a2771c/10.1177_17590914231152099-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/f0dc3f4bdf0b/10.1177_17590914231152099-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/fed27cfe6b9e/10.1177_17590914231152099-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/9d2d5a6fa64a/10.1177_17590914231152099-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/0278d8e1f562/10.1177_17590914231152099-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/b00f6eced9e6/10.1177_17590914231152099-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/521ae4e2cabb/10.1177_17590914231152099-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/79f9dce17038/10.1177_17590914231152099-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/56b5bb8b94b4/10.1177_17590914231152099-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/b8f2ade479b5/10.1177_17590914231152099-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/65aaa5220aff/10.1177_17590914231152099-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c1/9880594/f92847a2771c/10.1177_17590914231152099-fig11.jpg

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本文引用的文献

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2
Individual susceptibility has a major impact on strong association between oxidative stress, defence systems and Parkinson's disease.个体易感性对氧化应激、防御系统与帕金森病之间的强关联有重大影响。
Basic Clin Pharmacol Toxicol. 2022 Jan;130(1):158-170. doi: 10.1111/bcpt.13659. Epub 2021 Nov 7.
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Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP-exposed SH-SY5Y cells pre-treated with rutin.
槲皮素预处理对 MPP 暴露的 SH-SY5Y 细胞中 γH2AX、COX-2 的抑制作用及抗氧化酶的调节
Metab Brain Dis. 2021 Oct;36(7):2119-2130. doi: 10.1007/s11011-021-00746-z. Epub 2021 May 12.
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Transcription Factors Phox2a/2b Upregulate Expression of Noradrenergic and Dopaminergic Phenotypes in Aged Rat Brains.转录因子 Phox2a/2b 上调老年大鼠大脑中去甲肾上腺素能和多巴胺能表型的表达。
Neurotox Res. 2020 Oct;38(3):793-807. doi: 10.1007/s12640-020-00250-9. Epub 2020 Jul 2.
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DNA damage and repair in Parkinson's disease: Recent advances and new opportunities.帕金森病中的 DNA 损伤与修复：最新进展与新机遇。
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