帕金森病模型小鼠中上调的与 DNA 损伤相关的生物标志物。
Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice.
机构信息
Department of Neurology, Renmin Hospital of the Wuhan University, Wuhan, China.
Departments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, Johnson City, TN, USA.
出版信息
ASN Neuro. 2023 Jan-Dec;15:17590914231152099. doi: 10.1177/17590914231152099.
Abstract
The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.
摘要
本研究检测了 VMAT2 Lo PD 模型小鼠中 DNA 损伤标志物的表达。结果表明，这些 DNA 损伤标志物在 18 月龄和 23 月龄模型小鼠的大脑区域中显著增加，表明氧化应激诱导的 DNA 损伤是该小鼠模型的一个重要病理特征。
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