Yildirim Ali, Keles Fatma, Kosger Pelin, Ozdemir Gokmen, Ucar Birsen, Kilic Zubeyir
Department of Pediatric Cardiology, Medical Faculty, Eskisehir Osmangazi University, 26480 Eskisehir, Turkey.
Int J Chronic Dis. 2015;2015:747082. doi: 10.1155/2015/747082. Epub 2015 Aug 24.
This study evaluated uric acid concentrations in normotensive children of parents with hypertension. Eighty normotensive children from families with and without a history of essential hypertension were included. Concentrations of lipid parameters and uric acid were compared. Demographic and anthropometric characteristics were similar in the groups. Systolic and diastolic blood pressure were higher in the normotensive children of parents with hypertension without statistically significant difference (P > 0.05). Uric acid concentrations were higher in the normotensive children of parents with hypertension (4.61 versus 3.57 mg/dL, P < 0.01). Total cholesterol and triglyceride concentrations were similar in the two groups. Systolic and diastolic blood pressure were significantly higher in control children aged >10 years (P < 0.01). Uric acid levels were significantly higher in all children with more pronounced difference after age 10 of years (P < 0.001). Positive correlations were found between the level of serum uric acid and age, body weight, body mass index, and systolic and diastolic blood pressure in the normotensive children of parents. The higher uric acid levels in the normotensive children of hypertensive parents suggest that uric acid may be a predeterminant of hypertension. Monitoring of uric acid levels in these children may allow for prevention or earlier treatment of future hypertension.
本研究评估了父母患有高血压的血压正常儿童的尿酸浓度。纳入了80名来自有和没有原发性高血压病史家庭的血压正常儿童。比较了血脂参数和尿酸的浓度。两组的人口统计学和人体测量学特征相似。父母患有高血压的血压正常儿童的收缩压和舒张压较高，但无统计学显著差异（P>0.05）。父母患有高血压的血压正常儿童的尿酸浓度较高（4.61对3.57mg/dL，P<0.01）。两组的总胆固醇和甘油三酯浓度相似。10岁以上对照儿童的收缩压和舒张压显著较高（P<0.01）。所有儿童的尿酸水平显著较高，10岁以后差异更明显（P<0.001）。在父母血压正常的儿童中，血清尿酸水平与年龄、体重、体重指数以及收缩压和舒张压之间存在正相关。高血压父母的血压正常儿童中较高的尿酸水平表明，尿酸可能是高血压的一个预先决定因素。监测这些儿童的尿酸水平可能有助于预防或更早治疗未来的高血压。
