Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, United Kingdom.
School of Physiology and Pharmacology, Bristol University , Bristol, BS8 1TD, United Kingdom.
eNeuro. 2015 Mar 23;2(1). doi: 10.1523/ENEURO.0046-14.2015. eCollection 2015 Jan-Feb.
Visual recognition memory relies on long-term depression-like mechanisms within the perirhinal cortex and the activation of the lateral amygdala can enhance visual recognition memory. How the lateral amygdala regulates recognition memory is not known, but synaptic plasticity at amygdala-perirhinal synapses may provide a mechanism for the emotional enhancement of recognition memory. In this study, we investigate the mechanisms of long-term depression (LTD) at the amygdala-perirhinal synapse in male Lister Hooded rats. We demonstrate that LTD at this input relies on NR2A-containing NMDARs, located presynaptically. Therefore, the underlying mechanisms of LTD, at the amygdala-perirhinal input, which may regulate the emotional context for recognition memory, are different to previously described postsynaptic NR2B-NMDAR mechanisms of intraperirhinal LTD that subserve recognition memory.
视觉识别记忆依赖于边缘系统皮层内的长时程压抑样机制，而外侧杏仁核的激活可以增强视觉识别记忆。然而，外侧杏仁核如何调节识别记忆尚不清楚，但杏仁核-边缘系统突触的突触可塑性可能为识别记忆的情绪增强提供了一种机制。在这项研究中，我们研究了在雄性 Lister Hooded 大鼠的杏仁核-边缘系统突触处长时程压抑（LTD）的机制。我们证明，这种输入处的 LTD 依赖于位于突触前的含有 NR2A 的 NMDA 受体。因此，可能调节识别记忆的情绪背景的杏仁核-边缘系统输入处 LTD 的潜在机制，与先前描述的支持识别记忆的内边缘系统 LTD 的突触后 NR2B-NMDA 受体机制不同。
