Harbeck B, Haas C S, Suefke S, Kropp P, Moenig H
Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.
Institute of Medical Psychology and Medical Sociology, University of Rostock, Germany.
Exp Clin Endocrinol Diabetes. 2015 Oct;123(9):571-4. doi: 10.1055/s-0035-1559630. Epub 2015 Oct 14.
Headache and depression are common problems in patients with hypothalamic-pituitary disorders (HPD).
To determine the prevalence of headache and depression in patients with HPD and the specific characteristics in affected individuals in comparison to patients with cardiovascular problems (CD).
Patients with HPD and CD were asked to complete a questionnaire regarding headache and depression.
There were no significant differences between the HPD and the CD group. Prevalence of headache was not associated with the treatment modality of pituitary disease, hormone excess syndromes or any hormonal replacement therapy. However, ACTH, TSH and GH deficiency were associated with less headache when compared to patients with adequate secretion. Interestingly, patients who had prior surgery suffered significantly more often from depression. In addition, headache and depression were significantly more common in patients with microadenomas than in macroadenomas.
The risk for headache and depression is mainly influenced by a combination of factors, but a specific pituitary hormone deficiency may decrease risk for headache.
头痛和抑郁是下丘脑 - 垂体疾病（HPD）患者的常见问题。
确定HPD患者中头痛和抑郁的患病率，以及与心血管疾病（CD）患者相比，受影响个体的具体特征。
要求HPD和CD患者完成一份关于头痛和抑郁的问卷。
HPD组和CD组之间无显著差异。头痛的患病率与垂体疾病的治疗方式、激素过多综合征或任何激素替代疗法无关。然而，与分泌正常的患者相比，促肾上腺皮质激素（ACTH）、促甲状腺激素（TSH）和生长激素（GH）缺乏与头痛较少相关。有趣的是，曾接受手术的患者患抑郁症的频率明显更高。此外，微腺瘤患者头痛和抑郁的发生率明显高于大腺瘤患者。
头痛和抑郁的风险主要受多种因素综合影响，但特定的垂体激素缺乏可能会降低头痛风险。
