Michalik Martyna, Łapicka Justyna, Sota Marcin, Zawieska Julia, Grodzka Olga, Kępczyńska Katarzyna
Department of Neurology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Ceglowska 80, 01-809 Warsaw, Poland.
Doctoral School, Medical University of Warsaw, Ceglowska 80, 01-809 Warsaw, Poland.
J Clin Med. 2025 Jul 1;14(13):4645. doi: 10.3390/jcm14134645.
: Hypothyroidism is defined as a deficiency of thyroid hormones and is further classified into primary, secondary, and tertiary types, based on the root cause of the deficiency. Migraine is a primary headache disorder, characterized by unilateral, pulsating pain, lasting from 4 to 72 h, accompanied by symptoms such as photophobia, phonophobia, nausea, and emesis and sometimes preceded by specific aura phenomena. Both diseases are more prevalent in women than in men. While the primary focus of this systematic review was on the relationship between hypothyroidism and migraine, we also included relevant data on headaches in general when they provided valuable context or mechanistic insight. : This systematic review aimed to summarize the current knowledge about the relationship between migraine and hypothyroidism. The Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines were applied. Screening of two databases led to including 29 relevant studies in the review. : Studies demonstrated that migraine and disturbed thyroid function may influence one another. The positive correlation between migraine and hypothyroidism, mainly Hashimoto's disease, was presented in several studies. Moreover, some research identified this correlation in pediatric populations. Finally, the effects of levothyroxine use, a treatment applied in hypothyroidism, on migraine course were presented. : A better understanding of the correlation between migraine and hypothyroidism may lead to an increase in the understanding of the pathogenesis of both disorders and positively impact clinical practice.
甲状腺功能减退症被定义为甲状腺激素缺乏，并根据缺乏的根本原因进一步分为原发性、继发性和三发性类型。偏头痛是一种原发性头痛疾病，其特征为单侧搏动性疼痛，持续4至72小时，伴有畏光、畏声、恶心和呕吐等症状，有时还会出现特定的先兆现象。这两种疾病在女性中比在男性中更为普遍。虽然本系统评价的主要重点是甲状腺功能减退症与偏头痛之间的关系，但当有关头痛的相关数据能提供有价值的背景信息或机制见解时，我们也将其纳入。：本系统评价旨在总结目前关于偏头痛与甲状腺功能减退症之间关系的知识。应用了系统评价的首选报告项目（PRISMA）指南。对两个数据库的筛选导致在评价中纳入了29项相关研究。：研究表明，偏头痛和甲状腺功能紊乱可能相互影响。几项研究呈现了偏头痛与甲状腺功能减退症（主要是桥本氏病）之间的正相关。此外，一些研究在儿科人群中也发现了这种相关性。最后，还介绍了用于治疗甲状腺功能减退症的左甲状腺素对偏头痛病程的影响。：更好地理解偏头痛与甲状腺功能减退症之间的相关性可能会增进对这两种疾病发病机制的理解，并对临床实践产生积极影响。
