Gács G
Orv Hetil. 1989 Feb 19;130(8):383-7.
Twenty four children with hypopituitarism were treated with growth hormone from 6-15 years of age until cessation of growth. The height deficit decreased from -4.2SD to -2.2SD. Final height was above the 3rd percentile in half of the patients. There was no difference in final height between patients with and without additional gonadotropin deficiency. Spontaneous puberty started late but at a normal bone age and its course was normal. In girls with gonadotropin deficiency low dose oestrogen given at unchanged growth hormone doses did not accelerate growth. Final height was closely correlated with the degree of growth retardation at the beginning of treatment (r = 0.73, p less than 0.001). In 17 of the 79 patients treated with growth hormone compliance was bad. The main cause of bad compliance was the low educational level of the parents. It is concluded that final height in growth hormone deficiency can be increased with earlier diagnosis and improved compliance.
24名垂体功能减退的儿童在6至15岁期间接受生长激素治疗，直至生长停止。身高缺陷从-4.2标准差降至-2.2标准差。半数患者的最终身高高于第3百分位。伴有和不伴有额外促性腺激素缺乏的患者最终身高无差异。自发青春期开始较晚，但骨龄正常，其过程正常。对于促性腺激素缺乏的女孩，在生长激素剂量不变的情况下给予低剂量雌激素并不能加速生长。最终身高与治疗开始时的生长迟缓程度密切相关（r = 0.73，p < 0.001）。在79名接受生长激素治疗的患者中，有17名依从性差。依从性差的主要原因是父母教育水平低。结论是，通过早期诊断和改善依从性，可以提高生长激素缺乏患者的最终身高。
