De Luca F, Maghnie M, Arrigo T, Lombardo F, Messina M F, Bernasconi S
University of Messina, Italy.
Acta Paediatr. 1996 Oct;85(10):1167-71.
Thirteen growth hormone deficient infants underwent substitutive treatment for a least 9 years, since less than 5 years of age until adulthood. They presented with average growth failure reaching 4.1 SDS and attained an adult mean height close to target height. In eight subjects final height exceeded the respective target height and only three patients failed to achieve an end height within the target range. The analysis of the factors conditioning ultimate stature pointed out that height outcome correlated negatively with chronological age at therapy initiation and positively with height at puberty onset. It is concluded that full catch-up growth to target percentile is possible in growth hormone-deficient children, provided that substitutive treatment is begun within the 5 years of life. This conclusion is substantiated for the first time by data on end stature.
13名生长激素缺乏的婴儿接受了至少9年的替代治疗，从不到5岁开始直至成年。他们平均生长迟缓达4.1标准差，成年后的平均身高接近目标身高。8名受试者的最终身高超过了各自的目标身高，只有3名患者未能达到目标范围内的终身高。对决定最终身高的因素分析表明，身高结果与开始治疗时的实际年龄呈负相关，与青春期开始时的身高呈正相关。得出的结论是，生长激素缺乏的儿童只要在5岁前开始替代治疗，就有可能完全追赶生长至目标百分位数。这一结论首次得到终身高数据的证实。
