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低剂量劳拉西泮治疗有效的恶性紧张症:病例报告

Malignant catatonia responsive to low doses of lorazepam: case report.

作者信息

Matias Diego Fernando Moreira, Ando Sabrina de Mello, Riera Rachel, Góis Aécio Flávio Teixeira de

机构信息

Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.

Universidade Federal de São Paulo, São Paulo, Brazil.

出版信息

Sao Paulo Med J. 2016 Apr;134(2):176-9. doi: 10.1590/1516-3180.2014.00052608. Epub 2015 Oct 9.

Abstract

CONTEXT

Catatonia can be divided into non-malignant or malignant. The latter is characterized by autonomic instability, exhibiting high fever, tachycardia and hypertension, and is regarded as a fulminant and rapidly progressive subtype.

CASE REPORT

This article reports a case of malignant catatonia in a 43-year-old patient who had been presenting psychiatric disorders for the last three years. The patient was stable, maintaining mutism, immobility and autonomic abnormalities. Oral lorazepam (1 mg every eight hours) was introduced and, in a few hours, the patient became afebrile. Two days later, the patient was already responding to verbal commands.

CONCLUSIONS

Early intervention with lorazepam reduced the evolution of this patient to a fatal complication. Therefore, this case report sought to show that early diagnosis and intervention reduced the occurrence of serious and irreversible clinical outcomes.

摘要

背景

紧张症可分为非恶性或恶性。后者的特征是自主神经不稳定,表现为高热、心动过速和高血压,被视为暴发性且进展迅速的亚型。

病例报告

本文报告了一例43岁患者的恶性紧张症病例,该患者在过去三年中一直患有精神疾病。患者病情稳定,保持缄默、不动及自主神经异常。给予口服劳拉西泮(每八小时1毫克),数小时后患者体温恢复正常。两天后,患者已能对言语指令做出反应。

结论

劳拉西泮的早期干预减少了该患者发展为致命并发症的可能性。因此,本病例报告旨在表明早期诊断和干预可减少严重且不可逆临床结局的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9758/10496534/49d6a91acf67/1806-9460-spmj-134-02-176-gf1.jpg

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