Lin Chin-Chuen, Hung Yi-Yung, Tsai Meng-Chang, Huang Tiao-Lai
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
PLoS One. 2017 Jan 23;12(1):e0170452. doi: 10.1371/journal.pone.0170452. eCollection 2017.
The lorazepam-diazepam protocol had been proved to rapidly and effectively relieve catatonia in patients with schizophrenia or mood disorder. This study aims to investigate the efficacy of lorazepam-diazepam protocol in catatonia due to general medical conditions (GMC) and substance.
Patients with catatonia that required psychiatric intervention in various settings of a medical center were included. The lorazepam-diazepam protocol had been used to treat the catatonia due to GMC or substance according to DSM-IV criteria. The treatment response had been assessed by two psychiatrists.
Eighteen (85.7%) of 21 catatonic patients due to GMC or substance became free of catatonia after the lorazepam-diazepam protocol. Five (23.8%) of the 21 patients had passed away with various causes of death and wide range of time periods after catatonia.
Our results showed that the lorazepam-diazepam protocol could rapidly and effectively relieve catatonia due to GMC and substance.
劳拉西泮 - 地西泮方案已被证明能快速有效地缓解精神分裂症或心境障碍患者的紧张症。本研究旨在探讨劳拉西泮 - 地西泮方案对由一般躯体疾病（GMC）和物质所致紧张症的疗效。
纳入在医疗中心不同科室需要精神科干预的紧张症患者。根据《精神疾病诊断与统计手册》第四版（DSM-IV）标准，采用劳拉西泮 - 地西泮方案治疗由GMC或物质所致的紧张症。由两名精神科医生评估治疗反应。
21例由GMC或物质所致的紧张症患者中，18例（85.7%）在接受劳拉西泮 - 地西泮方案治疗后紧张症症状消失。21例患者中有5例（23.8%）在紧张症出现后因各种原因在不同时间段死亡。
我们的结果表明，劳拉西泮 - 地西泮方案能快速有效地缓解由GMC和物质所致的紧张症。
