Karamali M, Heidarzadeh Z, Seifati S-M, Samimi M, Tabassi Z, Talaee N, Bahardoost H, Asemi Z
Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, I.R. Iran.
Department of Biology, Islamic Azad University, Ashkezar branch, Ashkezar, Iran.
Exp Clin Endocrinol Diabetes. 2016 Jan;124(1):28-33. doi: 10.1055/s-0035-1564146. Epub 2015 Oct 14.
The current study was designed to determine the beneficial effects of zinc intake on biomarkers of inflammation, oxidative stress, and pregnancy outcomes among pregnant women with gestational diabetes (GDM).
This randomized, double-blind, placebo-controlled clinical trial was conducted among 50 women with GDM. Patients were randomly allocated to intake either 233 mg zinc gluconate (containing 30 mg zinc) (n=25) or a placebo (n=25) for 6 weeks. Fasting blood samples were taken at the fist of the study and after 6 weeks of intervention to quantify related variables. Newborn's weight, height, head circumference, Apgar score, and hyperbilirubinemia were determined.
The change in serum zinc levels after 6 weeks of supplementation was greater in women consuming zinc than in the placebo group (+8.5±13.5 vs. -3.6±16.2 mg/dL, P=0.006). Changes in serum high sensitivity C-reactive protein (hs-CRP) (-110.1±1 475.5 vs. +1 137.8±2 429.2 ng/mL, P=0.03) and plasma total antioxidant capacity (TAC) concentrations (+60.0±129.0 vs. -28.4±81.4 mmol/L, P=0.006) were significantly different between the supplemented women and placebo group. We did not find any significant effect of zinc administration on pregnancy outcomes.
Taken together, zinc administration among patients with GDM was associated with decreased hs-CRP and increased TAC concentrations; however, it did not influence maternal plasma nitric oxide (NO), glutathione (GSH), malondialdehyde (MDA) levels, or pregnancy outcomes.
本研究旨在确定锌摄入对妊娠期糖尿病（GDM）孕妇炎症、氧化应激生物标志物及妊娠结局的有益影响。
本随机、双盲、安慰剂对照临床试验在50例GDM女性中进行。患者被随机分配摄入233毫克葡萄糖酸锌（含30毫克锌）（n = 25）或安慰剂（n = 25），为期6周。在研究开始时和干预6周后采集空腹血样，以量化相关变量。测定新生儿的体重、身高、头围、阿氏评分和高胆红素血症。
补充锌6周后，补锌女性血清锌水平的变化大于安慰剂组（+8.5±13.5对-3.6±16.2毫克/分升；P = 0.006）。补充锌的女性与安慰剂组之间血清高敏C反应蛋白（hs-CRP）（-110.1±1475.5对+1137.8±2429.2纳克/毫升；P = 0.03）和血浆总抗氧化能力（TAC）浓度（+60.0±129.0对-28.4±81.4毫摩尔/升；P = 0.006）的变化有显著差异。我们未发现锌给药对妊娠结局有任何显著影响。
综上所述，GDM患者补锌与hs-CRP降低和TAC浓度升高相关；然而，它并未影响母体血浆一氧化氮（NO）、谷胱甘肽（GSH）、丙二醛（MDA）水平或妊娠结局。
