Javaud Nicolas, Charpentier Stéphane, Lapostolle Frédéric, Lekouara Hakim, Boubaya Marouane, Lenoir Gilles, Mekinian Arsène, Adnet Frédéric, Fain Olivier
Emergency Department, Angioedema Reference Center (CRéAk), Public Assistance Hospital of Paris, University Hospital of Jean Verdier, France.
Intern Med. 2015;54(20):2583-8. doi: 10.2169/internalmedicine.54.4181. Epub 2015 Oct 15.
Objective There appears to be differences in the clinical presentation of hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced (ACE-I) angioedema (AE). The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospective study of consecutive patients with HAE or ACE-I AE. The attack characteristics experienced by the patients were compared by a logistic regression analysis using generalized estimating equations. Results A total of 56 patients were included in this study (ACE-I AE, n=25; HAE, n=31). A total of 534 attacks were documented. Severe attacks were more common in the patients who had an acute episode of ACE-I AE than HAE. Swelling of the tongue, lips and larynx were significantly associated with ACE-I AE [OR: 8.70 (95% CI, 1.04-73.70), OR: 20.4 (95% CI, 4.9-84.2) and OR: 7.50 (95% CI, 1.20-48.30), respectively]. Conclusion Swelling of the tongue, lips and larynx are significantly more frequent in drug-induced AE than HAE.
目的 遗传性血管性水肿（HAE）和血管紧张素转换酶抑制剂诱导的（ACE-I）血管性水肿（AE）在临床表现上似乎存在差异。本研究的目的是比较这两种血管性水肿形式的临床特征。方法 我们对连续性的HAE或ACE-I AE患者进行了一项回顾性研究。使用广义估计方程通过逻辑回归分析比较患者经历的发作特征。结果 本研究共纳入56例患者（ACE-I AE，n = 25；HAE，n = 31）。共记录了534次发作。与HAE相比，ACE-I AE急性发作患者的严重发作更为常见。舌、唇和喉部肿胀与ACE-I AE显著相关[比值比分别为：8.70（95%置信区间，1.04 - 73.70）、20.4（95%置信区间，4.9 - 84.2）和7.50（95%置信区间，1.20 - 48.30）]。结论 药物诱导的血管性水肿中舌、唇和喉部肿胀的发生频率显著高于HAE。
