Prevete Nella, Liotti Federica, Marone Gianni, Melillo Rosa Marina, de Paulis Amato
Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131 Naples, Italy.
Department of Molecular Medicine and Medical Biotechnology (DMMBM), University of Naples Federico II, 80131 Naples, Italy; Institute of Endocrinology and Experimental Oncology (IEOS) "G. Salvatore", CNR, 80131 Naples, Italy.
Pharmacol Res. 2015 Dec;102:184-91. doi: 10.1016/j.phrs.2015.09.017. Epub 2015 Oct 20.
N-formyl peptide receptors (FPRs) belong to the family of pattern recognition receptors (PRRs) that regulate innate immune responses. Three FPRs have been identified in humans: FPR1-FPR3. FPR expression was initially described in immune cells and subsequently in non-hematopoietic cells and certain tissues. Besides their involvement in inflammatory disorders, FPRs have been implicated in the regulation of tissue repair and angiogenesis. Angiogenesis is not only a key component of pathogen defence during acute infection and of chronic inflammatory disorders, but also plays a critical role in wound healing and tissue regeneration. Moreover, pathologic uncontrolled angiogenesis is central for tumour growth, progression, and the formation of metastases. In this review, we summarise the evidence for a central role of FPRs at the intersection between inflammation, physiologic angiogenesis and pathologic neovascularisation linked to cancer. These findings provide insights into the potential clinical relevance of new treatment regimens involving FPR modulation.
N-甲酰肽受体（FPRs）属于调节先天性免疫反应的模式识别受体（PRRs）家族。在人类中已鉴定出三种FPR：FPR1 - FPR3。FPR的表达最初在免疫细胞中被描述，随后在非造血细胞和某些组织中也有发现。除了参与炎症性疾病外，FPRs还与组织修复和血管生成的调节有关。血管生成不仅是急性感染期间病原体防御和慢性炎症性疾病的关键组成部分，而且在伤口愈合和组织再生中也起着关键作用。此外，病理性不受控制的血管生成是肿瘤生长、进展和转移形成的核心。在本综述中，我们总结了FPRs在炎症、生理性血管生成和与癌症相关的病理性新血管形成之间的交叉点上发挥核心作用的证据。这些发现为涉及FPR调节的新治疗方案的潜在临床相关性提供了见解。
