Zhang Dandan, Zhao Qiang, Wu Beili
CAS Key Laboratory of Receptor Research, Shanghai Institute of Mate-ria Medica, Chinese Academy of Sciences, Pudong, Shanghai 201203, China.
Mol Cells. 2015 Oct;38(10):836-42. doi: 10.14348/molcells.2015.0263. Epub 2015 Oct 15.
G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions.
G蛋白偶联受体（GPCRs）构成了最大且在生理上最重要的膜蛋白家族，该家族可识别多种环境刺激，并且是治疗众多疾病的药物靶点。GPCR结构研究的最新进展揭示了GPCR配体识别、激活和变构调节的分子机制，以及GPCR二聚化的结构基础。在本综述中，我们将讨论GPCR的结构特征以及GPCR生物学功能不同方面的结构见解。
