Yücel Hasan, Zorlu Ali, Kaya Hakkı, Yılmaz Mehmet Birhan
Department of Cardiology, Faculty of Medicine, Cumhuriyet University; Sivas-Turkey.
Anatol J Cardiol. 2016 Mar;16(3):154-8. doi: 10.5152/akd.2015.6093. Epub 2015 Apr 30.
Endothelial dysfunction, secondary to systemic inflammation and oxidative stress, is known to play a major role in the development and progression of atherosclerosis. It is hypothesized that the lower incidence of coronary artery disease in the premenopausal period in females when compared with males is associated with regular menstrual blood loss. We investigated whether regular blood donation (BD) is associated with improved endothelial function in healthy adult males.
Fifty young healthy male volunteers volunteers with a mean age of 30 ± 6 years without overt cardiovascular disease were enrolled to participate in serial consecutive BDs. Serum iron levels as oxidative stress parameters, flow-mediated dilatation (FMD) for endothelial function, 24-h mean diastolic blood pressure for peripheral vascular resistance identification, and high-sensitivity C-reactive protein (hs-CRP) levels as systemic inflammatory markers were evaluated before and after BD. This study used a prospective observational cohort design. Patients with cardiovascular and inflammatory diseases were excluded.
BD was found to improve FMD steadily and significantly when compared with the baseline (mean ± SD: 9.9% ± 3.8%, 10.44% ± 3.9%, 10.65% ± 3.9%, and 10.75 ± 3.9%, respectively, p=0.15, p=0.02, p=0.006 as compared with the baseline). A steady decrease was identified in hs-CRP levels after serial BDs, although this decrease was not statistically significant in the all phases (2.96 ± 3.3 mg/L, 2.26 ± 1.5 mg/L, and 2.12 ± 1.5 mg/L, respectively, p=0.829, p=0.558). The 24-h mean diastolic blood pressures were significantly lower in the chronic phase (77 ± 9 mm Hg, 75 ± 7 mm Hg, and 72 ± 8 mm Hg, respectively, p=0.50, p=0.003), whereas there was no significant change in iron levels in the acute and chronic phases (66 ± 32 mg/dL, 72 ± 43 mg/dL, and 68 ± 33 mg/dL, respectively, p=1.000, p=1.000).
The results of the study indicate that regular BD improves endothelial function.
继发于全身炎症和氧化应激的内皮功能障碍在动脉粥样硬化的发生和发展中起主要作用。据推测，与男性相比，女性绝经前冠状动脉疾病发病率较低与规律性月经失血有关。我们研究了定期献血（BD）是否与健康成年男性内皮功能改善相关。
招募50名平均年龄为30±6岁、无明显心血管疾病的年轻健康男性志愿者参与连续的系列献血。在献血前后评估血清铁水平作为氧化应激参数、用于评估内皮功能的血流介导的血管舒张（FMD）、用于识别外周血管阻力的24小时平均舒张压以及作为全身炎症标志物的高敏C反应蛋白（hs-CRP）水平。本研究采用前瞻性观察队列设计。排除患有心血管疾病和炎症性疾病的患者。
与基线相比，发现献血使FMD稳步且显著改善（平均值±标准差：分别为9.9%±3.8%、10.44%±3.9%、10.65%±3.9%和10.75±3.9%，与基线相比，p = 0.15、p = 0.02、p = 0.006）。系列献血后hs-CRP水平持续下降，尽管在所有阶段这种下降均无统计学意义（分别为2.96±3.3mg/L、2.26±1.5mg/L和2.12±1.5mg/L，p = 0.829、p = 0.558）。慢性期24小时平均舒张压显著降低（分别为77±9mmHg、75±7mmHg和72±8mmHg，p = 0.50、p = 0.003），而急性期和慢性期铁水平无显著变化（分别为66±32mg/dL、72±43mg/dL和68±33mg/dL，p = 1.000、p = 1.000）。
研究结果表明定期献血可改善内皮功能。
