Zhao Liyan, Chen Xin Guang, Liu Yaowu, Fang Zhen, Zhang Fengxiang
Section of Pacing and Electrophysiology, Division of Cardiology, the First Affiliated Hospital of Nanjing Medical University; Nanjing-China.
Anatol J Cardiol. 2016 Mar;16(3):165-9. doi: 10.5152/akd.2015.5999. Epub 2015 Apr 24.
A recent genome-wide association study (GWAS) identified a susceptibility single nucleotide polymorphism (SNP), rs17042171 on 4q25 for atrial fibrillation (AF). The aim of the present study was to investigate whether this association between rs17042171 and AF also exists in Chinese Han populations.
It was a case-control study. We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 AF-free controls. Genotyping was performed using the TaqMan allelic discrimination Assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models.
There was strongly significant difference between AF patients and control subjects regarding rs17042171 assumption of additive model (OR=2.20, 95% CI: 1.88-2.57, p=2.00 × 10(-22)), dominant model (OR=2.99; 95% CI: 2.19-4.09; p=6.47 × 10(-12)) and a recessive (OR=2.75; 95% CI: 2.21-3.43; p=1.30 × 10(-19)). In the stratification analysis based on age, gender, hypertension, diabetes and coronary artery disease, there was no significant difference of the associations for rs17042171 among the subgroups.
Our results indicated that rs17042171 confers an increased risk of AF in Chinese Han Populations and expanded the association to non-European ancestry populations for the first time.
近期一项全基因组关联研究（GWAS）确定了4q25上的一个单核苷酸多态性（SNP），即rs17042171与心房颤动（AF）易感性相关。本研究旨在调查rs17042171与AF之间的这种关联在中国汉族人群中是否也存在。
这是一项病例对照研究。我们共纳入了1593名中国汉族个体，包括597例AF患者和996例无AF的对照。采用TaqMan等位基因分型法进行基因分型。在逻辑回归模型中计算比值比（OR）和95%置信区间（CI）。
在rs17042171的加性模型（OR = 2.20，95%CI：1.88 - 2.57，p = 2.00×10(-22)）、显性模型（OR = 2.99；95%CI：2.19 - 4.09；p = 6.47×10(-12)）和隐性模型（OR = 2.75；95%CI：2.21 - 3.43；p = 1.30×10(-19)）下，AF患者与对照之间存在极显著差异。在基于年龄、性别、高血压、糖尿病和冠状动脉疾病的分层分析中，各亚组中rs17042171的关联无显著差异。
我们的结果表明，rs17042171在中国汉族人群中增加了AF的发病风险，并首次将这种关联扩展到非欧洲血统人群。
