Davies H S, Pollard S G, Calne R Y
Department of Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom.
Transplantation. 1989 Mar;47(3):524-7. doi: 10.1097/00007890-198903000-00025.
Human liver allografts deliver soluble class I (HLA-A and -B) transplantation antigens into the recipients' circulation. These molecules are detectable in recipient serum shortly after transplantation and they persist at high concentration for as long as the liver graft functions. Levels of graft-derived antigens in the recipient serum and self antigens in donor serum are comparable. Kinetic studies of these soluble antigens in donor and recipient show that donor antigens are continuously exported by the transplanted liver, while in the recipient, self antigens are derived from liver and other sources. At least two molecular forms of soluble HLA-A and -B antigens are present in sera from donors, recipients, and normal individuals. One form with m.w. approximately 50 kd seems to be a soluble monomer associated with beta 2-microglobulin, while the other forms of higher m.w. may be aggregates and/or complexes. Monitoring of these antigens in transplant recipients may be a useful indicator of graft pathology and function.
人肝同种异体移植物将可溶性I类（HLA - A和 - B）移植抗原释放到受者的循环系统中。这些分子在移植后不久就能在受者血清中检测到，并且只要肝移植物发挥功能，它们就会以高浓度持续存在。受者血清中移植物来源抗原的水平与供者血清中的自身抗原水平相当。对供者和受者体内这些可溶性抗原的动力学研究表明，移植肝脏持续输出供者抗原，而在受者体内，自身抗原则来源于肝脏和其他来源。供者、受者和正常个体的血清中至少存在两种分子形式的可溶性HLA - A和 - B抗原。一种分子量约为50kd的形式似乎是与β2 - 微球蛋白相关的可溶性单体，而其他分子量较高的形式可能是聚集体和/或复合物。监测移植受者体内的这些抗原可能是移植物病理和功能的有用指标。
