Xiao Y, Li S-L, Lin H-L, Lin Z-F, Zhu X-Z, Fan J-Y, Gao K, Zhang H-L, Lin L-R, Liu L-L, Tong M-L, Niu J-J, Yang T-C
Zhongshan Hospital,Medical College of Xiamen University,Xiamen,China.
Xiamen Huli District Maternity and Child Care Hospital,Xiamen,China.
Epidemiol Infect. 2016 Apr;144(6):1165-74. doi: 10.1017/S0950268815002344. Epub 2015 Oct 15.
This study aimed to comprehensively evaluate factors that influence the likelihood of syphilis infection from risk-taking behaviours and medical conditions. A retrospective case-control study was conducted by enrolling 664 syphilis inpatients (excluding 11 congenital syphilis patients) and 800 sex- and age-matched controls. Medical histories, clinical data and patient interview data were collected and subjected to logistic regression analyses. The prevalence of syphilis in the study population was 3·9% (675/17,304). By univariate analysis, syphilis infection was associated with migration between cities, marital status, smoking, reproductive history, hypertension, elevated blood urea nitrogen (BUN) and infection with hepatitis B virus (HBV) (P < 0·05). A high rate of syphilis-HBV co-infection was observed in HIV-negative patients and further research revealed an association between syphilis and specific HBV serological reactivity. Syphilis was also associated with the frequency, duration and status of tobacco use. Multivariate analysis indicated that syphilis infection was independently associated with migration between cities [adjusted odds ratio (aOR) 1·368, 95% confidence interval (CI) 1·048-1·785], current smoking (aOR 1·607, 95% CI 1·177-2·195), elevated BUN (aOR 1·782, 95% CI 1·188-2·673) and some serological patterns of HBV infection. To prevent the spread of infectious diseases, inpatients and blood donors should be tested for HIV, syphilis, HBV and HCV simultaneously.
本研究旨在全面评估影响因冒险行为和健康状况而感染梅毒可能性的因素。通过纳入664例梅毒住院患者（不包括11例先天性梅毒患者）和800例性别及年龄匹配的对照者，开展了一项回顾性病例对照研究。收集了病史、临床数据和患者访谈数据，并进行了逻辑回归分析。研究人群中梅毒的患病率为3.9%（675/17304）。单因素分析显示，梅毒感染与城市间迁移、婚姻状况、吸烟、生育史、高血压、血尿素氮（BUN）升高以及乙型肝炎病毒（HBV）感染有关（P<0.05）。在HIV阴性患者中观察到梅毒-HBV合并感染率较高，进一步研究揭示了梅毒与特定HBV血清学反应性之间的关联。梅毒还与烟草使用的频率、持续时间和状态有关。多因素分析表明，梅毒感染与城市间迁移[调整优势比（aOR）1.368，95%置信区间（CI）1.048-1.785]、当前吸烟（aOR 1.607，95%CI 1.177-2.195）、BUN升高（aOR 1.782，95%CI 1.188-2.673）以及HBV感染的某些血清学模式独立相关。为预防传染病传播，应对住院患者和献血者同时进行HIV、梅毒、HBV和HCV检测。
