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伊朗东北部硬斑病皮损中伯氏疏螺旋体的聚合酶链反应检测频率

Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran.

作者信息

Yazdanpanah Mohhamad Javad, Sharifi Norieh, Khooei Alireza, Banihashemi Mahnaz, Khaje-Daluee Mohammad, Shamsi Azadeh, Ghazvini Kiarash

机构信息

Department of Dermatology, Research Center for Skin Diseases and Cutaneous Leishmaniasis, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran.

Department of Pathology, Mashhad University of Medical Sciences, Mashhad, IR Iran.

出版信息

Jundishapur J Microbiol. 2015 Aug 27;8(8):e19730. doi: 10.5812/jjm.19730v2. eCollection 2015 Aug.

DOI:10.5812/jjm.19730v2
PMID:26468360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4601107/
Abstract

BACKGROUND

The etiology of morphea is still unknown. Borrelia spp. as a causative agent of morphea has been discussed since 1985, but the relationship remains uncertain.

OBJECTIVES

We aimed to find the frequency of Borrelia in morphea lesions by polymerase chain reaction (PCR) in northeast of Iran.

PATIENTS AND METHODS

Sixty six patients with morphea were prospectively included in the present study. For each patient, formalin-fixed, paraffin-embedded tissue blocks of skin lesion biopsies were examined for Borrelia spp. DNA using PCR.

RESULTS

No Borrelia DNA was detected by PCR in skin lesions of patients with morphea.

CONCLUSIONS

The result of this study showed no relationship between Borrelia infection and morphea lesions and in other word indicated that morphea, at least in Iran, is not caused by Borrelia spp.

摘要

背景

硬斑病的病因仍不清楚。自1985年以来，伯氏疏螺旋体作为硬斑病的病原体一直被讨论，但两者的关系仍不确定。

目的

我们旨在通过聚合酶链反应（PCR）检测伊朗东北部硬斑病皮损中伯氏疏螺旋体的检出率。

患者与方法

本研究前瞻性纳入了66例硬斑病患者。对每位患者，采用PCR检测福尔马林固定、石蜡包埋的皮肤病变活检组织块中的伯氏疏螺旋体DNA。

结果

硬斑病患者的皮肤病变经PCR检测未发现伯氏疏螺旋体DNA。

结论

本研究结果表明伯氏疏螺旋体感染与硬斑病皮损之间无关联，换句话说，至少在伊朗，硬斑病不是由伯氏疏螺旋体引起的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f81/4601107/c5580b2ad2a7/jjm-08-08-19730-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f81/4601107/c5580b2ad2a7/jjm-08-08-19730-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f81/4601107/c5580b2ad2a7/jjm-08-08-19730-g001.jpg

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本文引用的文献

1
Morphoea: a manifestation of infection with Borrelia species?硬斑病：疏螺旋体属感染的一种表现？
Br J Dermatol. 2007 Dec;157(6):1189-98. doi: 10.1111/j.1365-2133.2007.08235.x. Epub 2007 Oct 17.
2
Morphoea and Borrelia burgdorferi: results from the Scottish Highlands in the context of the world literature.硬斑病与伯氏疏螺旋体：基于世界文献背景下的苏格兰高地研究结果
Mol Pathol. 2002 Dec;55(6):374-8. doi: 10.1136/mp.55.6.374.
3
Morphoea is neither associated with features of Borrelia burgdorferi infection, nor is this agent detectable in lesional skin by polymerase chain reaction.
硬斑病既不与伯氏疏螺旋体感染的特征相关，通过聚合酶链反应在皮损中也检测不到该病原体。
Br J Dermatol. 2000 Oct;143(4):780-5. doi: 10.1046/j.1365-2133.2000.03775.x.
4
Evidence for Borrelia burgdorferi in morphea and lichen sclerosus.伯氏疏螺旋体在硬斑病和硬化性苔藓中的证据。
Int J Dermatol. 2000 Apr;39(4):278-83. doi: 10.1046/j.1365-4362.2000.00912.x.
5
Isolation of Borrelia afzelii from circumscribed scleroderma.从局限性硬皮病中分离出阿氏疏螺旋体。
Br J Dermatol. 1999 May;140(5):925-30. doi: 10.1046/j.1365-2133.1999.02828.x.
6
Borrelia burgdorferi DNA and Borrelia hermsii DNA are not associated with morphea or lichen sclerosus et atrophicus in the southwestern United States.
Arch Dermatol. 1997 Sep;133(9):1174.
7
No evidence for Borrelia burgdorferi infection in lesions of morphea and lichen sclerosus et atrophicus in Spain. A prospective study and literature review.西班牙硬斑病和萎缩性硬化性苔藓皮损中无伯氏疏螺旋体感染证据：一项前瞻性研究及文献综述
Acta Derm Venereol. 1997 Jul;77(4):299-304. doi: 10.2340/0001555577299304.
8
Detection of Borrelia burgdorferi DNA (B garinii or B afzelii) in morphea and lichen sclerosus et atrophicus tissues of German and Japanese but not of US patients.在德国和日本患者的硬斑病及硬化萎缩性苔藓组织中检测到伯氏疏螺旋体DNA（伽氏疏螺旋体或阿氏疏螺旋体），而在美国患者中未检测到。
Arch Dermatol. 1997 Jan;133(1):41-4.
9
Heterogeneity of Borrelia burgdorferi in the skin.皮肤中伯氏疏螺旋体的异质性。
Am J Dermatopathol. 1996 Dec;18(6):571-9. doi: 10.1097/00000372-199612000-00004.
10
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J Cutan Pathol. 1996 Aug;23(4):350-8. doi: 10.1111/j.1600-0560.1996.tb01309.x.