Howardy-Hansen P, Rasmussen J A, Jensen B N
Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Denmark.
Acta Anaesthesiol Scand. 1989 Feb;33(2):167-9. doi: 10.1111/j.1399-6576.1989.tb02883.x.
Residual curarization in the recovery room was evaluated in 19 patients randomly allocated to two groups with nine and ten patients in each group, respectively. In one group atracurium was used for relaxation, and gallamine was used in the other. Anaesthesia was achieved with thiopental, diazepam, fentanyl and nitrous oxide in oxygen. Mean train-of-four (TOF) ratio in the gallamine and atracurium group was 0.63 and 0.91, respectively. Fifty per cent of the patients in the gallamine group had TOF ratios below 0.70, and none of these patients were able to sustain a head lift for 5 s. All patients in the atracurium group had TOF ratios above 0.70, and all of them were able to lift their head for 5 s. All patients were fully awake when they were evaluated, and no patient had any sign of respiratory difficulty. We conclude that residual curarization in the recovery room remains a problem and that this problem seems to be reduced when muscle relaxants of intermediate duration of action are used for relaxation during operation.
对19例患者在恢复室的残余肌松情况进行了评估，这些患者被随机分为两组，每组分别有9例和10例患者。一组使用阿曲库铵进行肌松，另一组使用加拉明。采用硫喷妥钠、地西泮、芬太尼和氧化亚氮-氧气进行麻醉。加拉明组和阿曲库铵组的平均四个成串刺激（TOF）比值分别为0.63和0.91。加拉明组50%的患者TOF比值低于0.70，这些患者中没有一人能够抬头5秒。阿曲库铵组所有患者的TOF比值均高于0.70，并且他们都能够抬头5秒。评估时所有患者均已完全清醒，且没有患者有任何呼吸困难的迹象。我们得出结论，恢复室的残余肌松仍然是一个问题，并且当在手术期间使用中效肌松剂进行肌松时，这个问题似乎有所减轻。
