Levosimendan for Septic Myocardial Dysfunction: Not Yet Ready for Prime Time.
作者信息
Pang Diana, Aneja Rajesh K
机构信息
Departments of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA.
出版信息
Crit Care Med. 2015 Nov;43(11):2522-3. doi: 10.1097/CCM.0000000000001328.
Abstract
摘要
相似文献
1
Levosimendan for Septic Myocardial Dysfunction: Not Yet Ready for Prime Time.左西孟旦用于脓毒症性心肌功能障碍：尚未准备好广泛应用。
Crit Care Med. 2015 Nov;43(11):2522-3. doi: 10.1097/CCM.0000000000001328.
2
Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages.左西孟旦在盲肠结扎诱导的脓毒症小鼠和脂多糖刺激的巨噬细胞中的抗炎作用。
Crit Care Med. 2015 Nov;43(11):e508-20. doi: 10.1097/CCM.0000000000001269.
3
Role of levosimendan in sepsis and septic shock.左西孟旦在脓毒症和脓毒性休克中的作用。
Curr Opin Anaesthesiol. 2008 Apr;21(2):168-77. doi: 10.1097/ACO.0b013e3282f43c56.
4
In contrast to its anti-inflammatory and anti-apoptotic peripheral effect, levosimendan failed to induce a long-term neuroprotective effect in a rat model of mild septic encephalopathy: a pilot study.与左西孟旦的抗炎和抗凋亡外周效应相反，在轻度脓毒症脑病大鼠模型中，左西孟旦未能诱导出长期神经保护作用：一项初步研究。
Neurosci Lett. 2014 Feb 7;560:117-21. doi: 10.1016/j.neulet.2013.12.021. Epub 2013 Dec 17.
5
Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression.左西孟旦对脓毒症性心肌抑制时全身和局部血流动力学的影响。
Intensive Care Med. 2006 May;32(5):790; author reply 791-2. doi: 10.1007/s00134-006-0130-9. Epub 2006 Mar 23.
6
Levosimendan - a calcium sensitising agent with potential anti-arrhythmic properties.左西孟旦——一种具有潜在抗心律失常特性的钙离子增敏剂。
Int J Clin Pract. 2010 Jul;64(8):1148-54. doi: 10.1111/j.1742-1241.2010.02396.x.
7
Levosimendan's effect on platelet function in a rat sepsis model.左西孟旦对脓毒症大鼠血小板功能的影响。
Platelets. 2013;24(3):189-93. doi: 10.3109/09537104.2012.726755. Epub 2012 Oct 3.
8
Levosimendan increases portal blood flow and attenuates intestinal intramucosal acidosis in experimental septic shock.左西孟旦增加门脉血流量并减轻实验性脓毒性休克时的肠道黏膜内酸中毒。
Shock. 2010 Sep;34(3):275-80. doi: 10.1097/SHK.0b013e3181cd8c5b.
9
[The effects of levosimendan on the cardiac function and prognosis in elderly patients with septic shock and myocardial contractility impairment].[左西孟旦对老年感染性休克合并心肌收缩功能障碍患者心功能及预后的影响]
Zhonghua Nei Ke Za Zhi. 2018 Jun 1;57(6):423-428. doi: 10.3760/cma.j.issn.0578-1426.2018.06.006.
10
Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression.左西孟旦对脓毒症性心肌抑制时全身和局部血流动力学的影响。
Intensive Care Med. 2005 May;31(5):638-44. doi: 10.1007/s00134-005-2619-z. Epub 2005 Apr 6.
引用本文的文献
1
Levosimendan does not reduce the mortality of critically ill adult patients with sepsis and septic shock: a meta-analysis.左西孟旦并未降低脓毒症和脓毒性休克危重症成年患者的死亡率：一项荟萃分析。
Chin Med J (Engl). 2019 May 20;132(10):1212-1217. doi: 10.1097/CM9.0000000000000197.
2
Effect of levosimendan on mortality in severe sepsis and septic shock: a meta-analysis of randomised trials.左西孟旦对严重脓毒症和脓毒性休克死亡率的影响：一项随机试验的荟萃分析。
BMJ Open. 2018 Mar 30;8(3):e019338. doi: 10.1136/bmjopen-2017-019338.
本文引用的文献
1
Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages.左西孟旦在盲肠结扎诱导的脓毒症小鼠和脂多糖刺激的巨噬细胞中的抗炎作用。
Crit Care Med. 2015 Nov;43(11):e508-20. doi: 10.1097/CCM.0000000000001269.
2
Rho kinase regulates induction of T-cell immune dysfunction in abdominal sepsis.Rho 激酶调节腹腔脓毒症中 T 细胞免疫功能障碍的诱导。
Infect Immun. 2013 Jul;81(7):2499-506. doi: 10.1128/IAI.00126-13. Epub 2013 Apr 29.
3
Levosimendan modulates programmed forms of cell death through K(ATP) channels and nitric oxide.左西孟旦通过 K(ATP) 通道和一氧化氮调节细胞程序性死亡。
J Cardiovasc Pharmacol. 2011 Feb;57(2):246-58. doi: 10.1097/FJC.0b013e318204bb55.
4
Effects of intravenous and inhaled levosimendan in severe rodent sepsis.静脉注射和吸入左西孟旦对严重啮齿类动物脓毒症的影响。
Intensive Care Med. 2009 Aug;35(8):1412-9. doi: 10.1007/s00134-009-1481-9. Epub 2009 Apr 15.
5
Novel HMGB1-inhibiting therapeutic agents for experimental sepsis.实验性败血症的新型高迁移率族蛋白 B1 抑制治疗药物。
Shock. 2009 Oct;32(4):348-57. doi: 10.1097/SHK.0b013e3181a551bd.
6
Effects of levo- and dextrosimendan on NF-kappaB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli.左西孟旦和右西孟旦对炎症刺激下NF-κB介导的转录、诱导型一氧化氮合酶表达及一氧化氮生成的影响。
Br J Pharmacol. 2008 Nov;155(6):884-95. doi: 10.1038/bjp.2008.328. Epub 2008 Aug 18.
7
Actual incidence of global left ventricular hypokinesia in adult septic shock.成人感染性休克中全球左心室运动功能减退的实际发生率。
Crit Care Med. 2008 Jun;36(6):1701-6. doi: 10.1097/CCM.0b013e318174db05.
8
Role of levosimendan in sepsis and septic shock.左西孟旦在脓毒症和脓毒性休克中的作用。
Curr Opin Anaesthesiol. 2008 Apr;21(2):168-77. doi: 10.1097/ACO.0b013e3282f43c56.
9
Mechanisms of sepsis-induced organ dysfunction.脓毒症诱导器官功能障碍的机制。
Crit Care Med. 2007 Oct;35(10):2408-16. doi: 10.1097/01.ccm.0000282072.56245.91.
10
Effects of levosimendan on flow-mediated vasodilation and soluble adhesion molecules in patients with advanced chronic heart failure.左西孟旦对晚期慢性心力衰竭患者血流介导的血管舒张和可溶性黏附分子的影响。
Atherosclerosis. 2008 Mar;197(1):278-82. doi: 10.1016/j.atherosclerosis.2007.04.023. Epub 2007 Jun 12.
Zotero 插件