β-氨基丙腈降低高血压大鼠的血压和血管胶原蛋白含量
Reduction of blood pressure and vascular collagen in hypertensive rats by beta-aminopropionitrile.
作者信息
Iwatsuki K, Cardinale G J, Spector S, Udenfriend S
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):360-2. doi: 10.1073/pnas.74.1.360.
Abstract
beta-Aminopropionitrile, a specific inhibitor of lysyl oxidase prevented the rise in blood pressure induced by deoxycorticosterone-salt in rats. In addition, after the onset of hypertension, administration of beta-aminopropionitrile lowered the blood pressure. Concomitant with the lowering of blood pressure, there was a reduction in the more highly crosslinked form of vascular collagen. These findings would indicate that increases in vascular connective tissue are not only sequelae of hypertension, but may also contribute to the maintenance of elevated blood pressure.
摘要
β-氨基丙腈是赖氨酰氧化酶的一种特异性抑制剂，可阻止脱氧皮质酮-盐诱导的大鼠血压升高。此外，在高血压发作后，给予β-氨基丙腈可降低血压。伴随血压降低，血管胶原蛋白高度交联形式减少。这些发现表明，血管结缔组织增加不仅是高血压的后遗症，还可能有助于维持血压升高。
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