Praprotnik M, Stucin Gantar I, Lučovnik M, Avčin T, Krivec U
Department of Pulmonology, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Division of Perinatology, Department of Gynecology and Obstretics, University Medical Centre Ljubljana, Ljubljana, Slovenia.
J Perinatol. 2015 Dec;35(12):1037-42. doi: 10.1038/jp.2015.124. Epub 2015 Oct 15.
To examine respiratory morbidity and exercise capacity at school age in children after bronchopulmonary dysplasia (BPD).
Former preterm children after BPD (n=23), without BPD (n=33) and term controls (n=33) were compared using respiratory health questionnaire, spirometry and six-minute walk test (6MWT).
Wheezing was more frequent in BPD group (61%) vs non-BPD group (24%; P<0.001) and controls (15%; P<0.001) in the first year of life and until a year before inclusion. The children after BPD had lower mean value (P<0.001) for forced expiratory volume in 1 s (75.3%) vs non-BPD (89.8%) and controls (91.1%). Six-minute walking distance was lower after BPD by 58.3 m compared with non-BPD group (P=0.002) and by 53.7 m compared with controls (P=0.005). After adjusting for confounding factors the difference was not significant anymore.
More frequent wheezing and reduced lung function persist into school age after BPD.
研究支气管肺发育不良（BPD）患儿学龄期的呼吸道发病率和运动能力。
采用呼吸健康问卷、肺功能测定和六分钟步行试验（6MWT），对曾患BPD的早产儿童（n = 23）、未患BPD的早产儿童（n = 33）和足月儿对照组（n = 33）进行比较。
在出生后第一年直至纳入研究前一年，BPD组（61%）的喘息发生率高于非BPD组（24%；P<0.001）和对照组（15%；P<0.001）。BPD患儿的1秒用力呼气量平均值较低（P<0.001），为75.3%，而非BPD组为89.8%，对照组为91.1%。与非BPD组相比，BPD患儿的六分钟步行距离缩短了58.3米（P = 0.002），与对照组相比缩短了53.7米（P = 0.005）。在对混杂因素进行校正后，差异不再显著。
BPD患儿学龄期喘息更频繁，肺功能持续降低。
