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DyNAvectors:用于适应性DNA转染的动态构成载体

DyNAvectors: dynamic constitutional vectors for adaptive DNA transfection.

作者信息

Clima Lilia, Peptanariu Dragos, Pinteala Mariana, Salic Adrian, Barboiu Mihail

机构信息

Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy - 41A, Aleea Gr. Ghica Voda, Iasi, Romania.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Chem Commun (Camb). 2015 Dec 25;51(99):17529-31. doi: 10.1039/c5cc06715d.

DOI:10.1039/c5cc06715d
PMID:26469153
Abstract

Dynamic constitutional frameworks, based on squalene, PEG and PEI components, reversibly connected to core centers, allow the efficient identification of adaptive vectors for good DNA transfection efficiency and are well tolerated by mammalian cells.

摘要

基于角鲨烯、聚乙二醇(PEG)和聚乙烯亚胺(PEI)成分的动态结构框架,与核心中心可逆连接,能够高效识别具有良好DNA转染效率的适配载体,并且哺乳动物细胞对其耐受性良好。

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