Zhang Yan, Pham Chi-Yen, Yu Rui, Petit Eddy, Li Suming, Barboiu Mihail
Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, Wuxi, China.
Department of Pharmacological, Medical and Agronomical Biotechnology, Hanoi University of Science and Technology, Hanoi, Vietnam.
Front Chem. 2020 Aug 26;8:739. doi: 10.3389/fchem.2020.00739. eCollection 2020.
Dynamic hydrogels have been prepared by cross-linking of -carboxymethyl chitosan (-CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive drug release behaviors of the hydrogels. The structural and physical properties of the resulted hydrogels were examined, showing good thermal stability and higher swelling behaviors (up to 3,000%). When hydrogels with various composition ratios were further applied for delivery of anti-cancer drug fluorouracil (5-FU), high drug encapsulation rates were recorded, up to 97%. The release profile of 5-FU showed fast rate at the beginning, followed by slow increase to the maximum amount within 12 h, demonstrating potential as drug carriers for efficient drug delivery.
通过将羧甲基壳聚糖（-CMCS）与可逆连接的亚氨基聚乙二醇化二聚体交联制备了动态水凝胶。双亚胺壳聚糖/二聚体和二聚体键用于提供水凝胶更紧密的结构和适应性药物释放行为。对所得水凝胶的结构和物理性质进行了研究，结果表明其具有良好 的热稳定性和更高的溶胀行为（高达3000%）。当将具有不同组成比的水凝胶进一步用于递送抗癌药物氟尿嘧啶（5-FU）时，记录到了高达97%的高药物包封率。5-FU的释放曲线在开始时显示出快速释放，随后在12小时内缓慢增加至最大量，证明了其作为高效药物递送的药物载体的潜力。
