Gyorkos T W, Frappier-Davignon L, MacLean J D, Viens P
Department of Epidemiology and Biostatistics, McGill University, Montréal, Québec, Canada.
Am J Epidemiol. 1989 Apr;129(4):753-61. doi: 10.1093/oxfordjournals.aje.a115190.
A randomized, controlled trial was undertaken to evaluate the effects of a screening program for intestinal parasite infection in newly arrived Southeast Asian refugees to Montréal, Québec, Canada, during 1982-1983. Families assigned to the screened groups were examined, infected persons were treated and followed until they were infection-free, and all screened families were reexamined at six months. Families assigned to the control groups were examined at six months only. Statistically significant prevalence differences in unadjusted and adjusted estimates over the six-month study period were found between screened persons and controls for each of three groups of refugees from Kampuchea, Laos, and Vietnam, respectively. In general, the greatest prevalence differences ascribed to the screening program were observed in hookworm and Ascaris lumbricoides infections. Continued high levels of Giardia lamblia and Strongyloides stercoralis infection were observed at six months; this raises concerns over the effective therapeutic management of infected persons, the risk of local transmission, and the relevance of screening for intestinal parasites in new arrivals from endemic areas.
1982 - 1983年期间，在加拿大魁北克省蒙特利尔市开展了一项随机对照试验，以评估针对新抵达的东南亚难民进行肠道寄生虫感染筛查项目的效果。被分配到筛查组的家庭接受检查，感染者接受治疗并随访至无感染状态，所有接受筛查的家庭在六个月时重新接受检查。被分配到对照组的家庭仅在六个月时接受检查。在六个月的研究期内，分别对来自柬埔寨、老挝和越南的三组难民进行筛查的人与对照组相比，未调整和调整后的估计患病率差异具有统计学意义。总体而言，筛查项目导致的最大患病率差异出现在钩虫和蛔虫感染中。在六个月时观察到贾第虫和粪类圆线虫感染水平持续较高；这引发了对感染者有效治疗管理、局部传播风险以及对来自流行地区新抵达者进行肠道寄生虫筛查相关性的担忧。
