Gyorkos T W, MacLean J D, Law C G
Department of Epidemiology and Biostatistics, McGill University, Montreal General Hospital, Québec, Canada.
Am J Epidemiol. 1989 Nov;130(5):976-80. doi: 10.1093/oxfordjournals.aje.a115430.
The authors undertook a retrospective search of intestinal parasite laboratory records obtained from 200 consecutive-day pairs of stool specimens to compare prevalence estimates from the first and second stool examinations. The laboratory results had previously been recorded as part of a screening program offered to Southeast Asian refugees arriving in Montréal, Québec, Canada, between July 1982 and February 1983. No statistically significant differences in either overall prevalences or parasite-specific prevalences were observed. This suggests that, at least in some population-based situations, single stool examinations provide estimates of intestinal parasite prevalence which are as valid as those from the routine examination of two consecutive-day specimens. Blinded studies must be undertaken to accurately assess the true value of multiple specimen submission in epidemiologic studies.
作者对从连续200天的成对粪便标本中获得的肠道寄生虫实验室记录进行了回顾性检索，以比较第一次和第二次粪便检查的患病率估计值。这些实验室结果先前已作为1982年7月至1983年2月抵达加拿大魁北克省蒙特利尔的东南亚难民筛查项目的一部分进行记录。在总体患病率或寄生虫特异性患病率方面均未观察到统计学上的显著差异。这表明，至少在某些基于人群的情况下，单次粪便检查所提供的肠道寄生虫患病率估计值与连续两天标本的常规检查结果一样有效。必须进行盲法研究，以准确评估在流行病学研究中提交多个标本的真实价值。
