Luttrull Jeffrey K
Ophthalmic Surg Lasers Imaging Retina. 2015 Oct;46(9):976-8. doi: 10.3928/23258160-20151008-13.
Two consecutive cases of symptomatic vitreomacular adhesion with macular hole were treated with intravitreal ocriplasmin. Both were complicated by long-term visual symptoms and chronic serous foveal detachments lasting 17 months post-treatment. These findings suggest direct and long-lasting effects of ocriplasmin on the retinal pigment epithelium and/or outer retina. Patients treated with ocriplasmin should be cautioned that the side effects of even successful drug treatment may prolong visual recovery compared to vitrectomy.
两例连续的伴有黄斑裂孔的症状性玻璃体黄斑粘连患者接受了玻璃体内注射奥克纤溶酶治疗。两者均伴有长期视觉症状和治疗后持续17个月的慢性浆液性黄斑脱离。这些发现提示奥克纤溶酶对视网膜色素上皮和/或外层视网膜有直接和持久的作用。接受奥克纤溶酶治疗的患者应被告知，与玻璃体切除术相比，即使药物治疗成功，其副作用也可能延长视力恢复时间。
