Watabe Yaeko, Arisaka Osamu, Miyake Noriko, Ichikawa Go, Koyama Satomi, Shimura Naoto
1 Department of Pediatrics, Dokkyo Medical University , Mibu, Kitakobayashi, Japan .
2 Department of Clinical Pathology, Juntendo Nerima Hospital , Tokyo, Japan .
Metab Syndr Relat Disord. 2015 Dec;13(10):465-9. doi: 10.1089/met.2015.0054. Epub 2015 Oct 15.
Low-density lipoprotein (LDL) is atherogenic and LDL particles are reduced in diameter in the presence of insulin resistance, forming small, dense LDL. This study was conducted to assess the relationship between commonly used lipid indices and LDL particle size and furthermore to clarify the best surrogate lipid markers that could conveniently be used to estimate LDL particle size in children.
We determined LDL particle diameter by gradient gel electrophoresis in 1578 children aged 10-12 years. At the fasting state, the relationships between measured LDL particle size and lipid variables [total cholesterol (TC), triglycerides (TG), LDL-cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), atherogenic index [(TC-HDL-C)/HDL-C, TG/HDL-C, LDL-C/HDL-C, and LDL-C/apolipoprotein B (Apo B) and non-HDL-C (TC-HDL-C)] were analyzed.
The LDL particle diameter was 26.64 (mean) ± 0.48 (SD) nm in boys (n = 820) and 26.66 ± 0.49 nm in girls (n = 758); there was not a statistically significant difference. There were statistically significant correlations between LDL particle size and TG or HDL-C concentrations (r = 0.28∼0.37), but the correlations with LDL-C and ApoB were very weak. The combined lipid measures, such as atherogenic index, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C showed moderate correlations (r = 0.33∼0.38) with LDL particle size; however, the correlation of non-HDL-C with LDL particle size was weak (r = 0.18∼0.19). Simple HDL-C measure appeared to be of comparable value to combined lipid measures.
Our data indicate that various lipid indices are not superior to HDL-C levels alone as a clinical tool for estimating LDL particle size. Non-HDL-C was less valuable in this aspect.
低密度脂蛋白（LDL）具有致动脉粥样硬化性，在存在胰岛素抵抗的情况下，LDL颗粒直径减小，形成小而致密的LDL。本研究旨在评估常用血脂指标与LDL颗粒大小之间的关系，并进一步明确可方便用于估计儿童LDL颗粒大小的最佳替代血脂标志物。
我们通过梯度凝胶电泳测定了1578名10 - 12岁儿童的LDL颗粒直径。在空腹状态下，分析了测得的LDL颗粒大小与血脂变量[总胆固醇（TC）、甘油三酯（TG）、LDL胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、致动脉粥样硬化指数[（TC - HDL-C）/HDL-C、TG/HDL-C、LDL-C/HDL-C以及LDL-C/载脂蛋白B（Apo B）和非HDL-C（TC - HDL-C）]之间的关系。
男孩（n = 820）的LDL颗粒直径为26.64（均值）±0.48（标准差）nm，女孩（n = 758）为26.66±0.49nm；差异无统计学意义。LDL颗粒大小与TG或HDL-C浓度之间存在统计学显著相关性（r = 0.28∼0.37），但与LDL-C和ApoB的相关性非常弱。联合血脂指标，如致动脉粥样硬化指数、TC/HDL-C、TG/HDL-C和LDL-C/HDL-C与LDL颗粒大小呈中度相关性（r = 0.33∼0.38）；然而，非HDL-C与LDL颗粒大小的相关性较弱（r = 0.18∼0.19）。单纯的HDL-C测量似乎与联合血脂指标具有相当的价值。
我们的数据表明，作为估计LDL颗粒大小的临床工具，各种血脂指标并不优于单独的HDL-C水平。在这方面，非HDL-C的价值较小。
