Kojima M, Kanno H, Yamazaki Y, Koyama S, Kanazawa S, Arisaka O
Department of Paediatrics, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
Acta Paediatr. 2005 Mar;94(3):281-6. doi: 10.1111/j.1651-2227.2005.tb03070.x.
The objective of this study was to investigate whether the presence of small, dense lipoproteins, which are thought to be related to the metabolic syndrome caused by insulin resistance, can be predicted by routine serum lipid profiling.
The relationship between low-density lipoprotein (LDL) particle size and serum lipid levels was analysed in 284 school children (148 boys and 136 girls), aged 7 to 13 y old. LDL particle size was determined by gradient gel electrophoresis.
The LDL particle diameter was significantly correlated with the serum levels of high-density lipoprotein cholesterol (HDL-C) (r = - 0.437, p < 0.001) and triglycerides (TG) (r = -0.432, p < 0.001), and with the atherogenic index (AI) [total cholesterol/ HDL-C] (r = -0.450, p < 0.001), while only weak correlations were observed with the serum levels of total cholesterol, apolipoprotein Al and apolipoprotein B. No significant relationship was observed between LDL particle diameter and the serum LDL-C level.
The presence of small, dense LDL as a metabolic marker of lifestyle-related diseases in children seems to be reflected by a serum lipid profile characterized by an elevation in TG, a reduction in HDL-C, and a raised AI.
本研究的目的是调查常规血清脂质谱分析能否预测小而密的脂蛋白的存在，这种脂蛋白被认为与胰岛素抵抗引起的代谢综合征有关。
分析了284名7至13岁学龄儿童（148名男孩和136名女孩）的低密度脂蛋白（LDL）颗粒大小与血清脂质水平之间的关系。通过梯度凝胶电泳测定LDL颗粒大小。
LDL颗粒直径与血清高密度脂蛋白胆固醇（HDL-C）水平（r = -0.437，p < 0.001）和甘油三酯（TG）水平（r = -0.432，p < 0.001）以及致动脉粥样硬化指数（AI）[总胆固醇/HDL-C]（r = -0.450，p < 0.001）显著相关，而与血清总胆固醇、载脂蛋白A1和载脂蛋白B水平仅存在弱相关性。未观察到LDL颗粒直径与血清LDL-C水平之间存在显著关系。
儿童中作为生活方式相关疾病代谢标志物的小而密LDL的存在似乎通过以TG升高、HDL-C降低和AI升高为特征的血清脂质谱得以体现。
