Fadini Gian Paolo, Bonora Benedetta Maria, Marcuzzo Giorgio, Marescotti Maria Cristina, Cappellari Roberta, Pantano Giorgia, Sanzari Maria Colomba, Duran Xavier, Vendrell Joan, Plebani Mario, Avogaro Angelo
Department of Medicine (G.P.F., B.M.B., M.C.M., R.C., G.P., M.C.S., M.P., A.A.), University of Padova, 35128 Padova, Italy; Venetian Institute of Molecular Medicine (G.P.F., X.D., A.A.), 35128 Padova, Italy; Department of Cardiologic, Thoracic and Vascular Sciences (G.M.), Service of Preventive Medicine, University of Padova, 35128 Padova, Italy; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) (X.D., J.V.), Instituto de Salud Carlos III, Madrid, Spain; Joan XXIII University Hospital (J.V.), Rovira i Virgili University IISPV, Tarragona, Spain.
J Clin Endocrinol Metab. 2015 Dec;100(12):4570-8. doi: 10.1210/jc.2015-2867. Epub 2015 Oct 15.
Obesity and metabolic syndrome are associated with mild leukocytosis, but whether hematopoietic stem/progenitor cells (HSPCs) play a role in metabolic deterioration is unknown.
Our objective was to analyze the cross-sectional and longitudinal associations between CD34(+) HSPCs, adiposity, and metabolic syndrome features.
This is a cross-sectional study on 242 participants, 155 of whom were followed and included in a longitudinal assessment.
This study took place in a tertiary referral center for metabolic diseases.
Healthy working individuals attending a cardiovascular screening program (total n = 3158) and having a baseline measure of circulating CD34(+) cells participated.
We collected demographic and anthropometric data, cardiovascular risk factors, and metabolic syndrome parameters.
Participants (34.7% males, mean age 45.9 ± 0.5 years) were free from diabetes and cardiovascular disease. Cross-sectionally, absolute CD34(+) cell counts were directly correlated with body mass index and waist circumference, inversely correlated with high-density lipoprotein cholesterol and the quantitative insulin sensitivity check index, and were higher in individuals with the metabolic syndrome. The hematopoietic component contributed most to the association of CD34(+) cells with adiposity. During a 6.3-year follow-up, high absolute levels of CD34(+) cells were associated with increasing waist circumference, declining quantitative insulin sensitivity check index and high-density lipoprotein cholesterol, and with incidence of metabolic syndrome. Relative CD34(+) cell counts showed weaker associations with metabolic parameters than absolute levels, but were longitudinally associated with increasing waist circumference and metabolic syndrome development.
A mild elevation of circulating CD34(+) progenitor cells, reflecting expansion of HSPCs, is associated with adiposity and future metabolic deterioration in healthy individuals.
肥胖和代谢综合征与轻度白细胞增多有关，但造血干细胞/祖细胞（HSPCs）是否在代谢恶化中起作用尚不清楚。
我们的目的是分析CD34(+) HSPCs、肥胖和代谢综合征特征之间的横断面和纵向关联。
这是一项对242名参与者的横断面研究，其中155人接受随访并纳入纵向评估。
本研究在一家代谢疾病三级转诊中心进行。
参加心血管筛查项目（共3158人）且有循环CD34(+)细胞基线测量值的健康在职人员参与。
我们收集了人口统计学和人体测量数据、心血管危险因素和代谢综合征参数。
参与者（34.7%为男性，平均年龄45.9±0.5岁）无糖尿病和心血管疾病。横断面分析中，CD34(+)细胞绝对计数与体重指数和腰围直接相关，与高密度脂蛋白胆固醇和定量胰岛素敏感性检查指数呈负相关，且在代谢综合征患者中更高。造血成分对CD34(+)细胞与肥胖的关联贡献最大。在6.3年的随访中，CD34(+)细胞的高绝对水平与腰围增加、定量胰岛素敏感性检查指数和高密度脂蛋白胆固醇下降以及代谢综合征的发生有关。CD34(+)细胞相对计数与代谢参数的关联比绝对水平弱，但在纵向与腰围增加和代谢综合征发展有关联。
循环CD34(+)祖细胞的轻度升高反映了HSPCs的扩增，与健康个体的肥胖和未来代谢恶化有关。
