Norman D C, Chang M P, Castle S C, Van Zuylen J E, Taylor A N
Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, West Los Angeles, CA 90073.
Alcohol Clin Exp Res. 1989 Feb;13(1):69-72. doi: 10.1111/j.1530-0277.1989.tb00286.x.
The fetal alcohol syndrome is associated with altered immunity. We attempted to delineate the mechanism of the decline in cell-mediated immunity observed by others by using rats which were exposed to alcohol in utero and tested for immune integrity 3 months after birth. We found that concanavalin A-stimulated T-lymphoblast (Con A T-blast) cells that were obtained from ethanol-exposed rats had significantly diminished proliferative responses to both crude and recombinant interleukin 2 compared to those obtained from normal and nutritional controls. The blunted response of Con A T-blast cells to interleukin 2 may be a biomarker of fetal exposure to alcohol.
胎儿酒精综合征与免疫功能改变有关。我们试图通过使用在子宫内接触酒精并在出生后3个月进行免疫完整性测试的大鼠，来阐明其他人所观察到的细胞介导免疫下降的机制。我们发现，与从正常和营养对照组获得的细胞相比，从乙醇暴露大鼠获得的伴刀豆球蛋白A刺激的T淋巴母细胞（Con A T细胞）对粗制和重组白细胞介素2的增殖反应显著降低。Con A T细胞对白细胞介素2反应迟钝可能是胎儿暴露于酒精的一个生物标志物。
