Blatteau Jean-Eric, David Hélène N, Vallée Nicolas, Meckler Cedric, Demaistre Sebastien, Lambrechts Kate, Risso Jean-Jacques, Abraini Jacques H
Institut de Recherche Biomédicale des Armées, Équipe Résidente de Recherche Subaquatique Opérationnelle, BP 600 Toulon Cedex 9, France.
Centre de recherche Hôtel-Dieu de Lévis, CSSS Alphonse-Desjardins, Lévis, QC, Canada.
Sci Rep. 2015 Oct 15;5:15093. doi: 10.1038/srep15093.
Despite state-of-the-art hyperbaric oxygen (HBO) treatment, about 30% of patients suffering neurologic decompression sickness (DCS) exhibit incomplete recovery. Since the mechanisms of neurologic DCS involve ischemic processes which result in excitotoxicity, it is likely that HBO in combination with an anti-excitotoxic treatment would improve the outcome in patients being treated for DCS. Therefore, in the present study, we investigated the effect of the noble gas xenon in an ex vivo model of neurologic DCS. Xenon has been shown to provide neuroprotection in multiple models of acute ischemic insults. Fast decompression compared to slow decompression induced an increase in lactate dehydrogenase (LDH), a well-known marker of sub-lethal cell injury. Post-decompression administration of xenon blocked the increase in LDH release induced by fast decompression. These data suggest that xenon could be an efficient additional treatment to HBO for the treatment of neurologic DCS.
尽管采用了最先进的高压氧（HBO）治疗，但约30%的神经性减压病（DCS）患者恢复不完全。由于神经性DCS的机制涉及导致兴奋性毒性的缺血过程，HBO联合抗兴奋性毒性治疗可能会改善DCS患者的治疗效果。因此，在本研究中，我们在神经性DCS的体外模型中研究了稀有气体氙的作用。氙已被证明在多种急性缺血性损伤模型中具有神经保护作用。与缓慢减压相比，快速减压导致乳酸脱氢酶（LDH）增加，LDH是亚致死性细胞损伤的一个众所周知的标志物。减压后给予氙可阻止快速减压诱导的LDH释放增加。这些数据表明，氙可能是HBO治疗神经性DCS的一种有效的辅助治疗方法。
