Foster M C, Wenham P W, Rowe P A, Burden R P, Morgan A G, Cotton R E, Blamey R W
Department of Surgery, City Hospital, Nottingham.
Ann R Coll Surg Engl. 1989 Jan;71(1):44-7.
The results of 279 renal transplants performed in a single centre between 1974 and 1986 are reviewed. Improvements in the management of acute rejection and a reduction in mortality have resulted in an improvement in 1-year actuarial graft survival rates from 44% for transplants performed before 1980 to 68% for those performed after 1983. After the second year post-transplant there has been a steady rate of graft failure (6% per annum), mainly due to chronic rejection. In total 52 grafts have developed chronic rejection (19% of the total and 30% of those at risk at 6 months). Chronic rejection is assuming greater relative importance as a cause of graft loss as early results improve.
回顾了1974年至1986年在单一中心进行的279例肾移植结果。急性排斥反应管理的改善和死亡率的降低，使1年移植肾精算存活率从1980年前进行的移植的44%提高到1983年后进行的移植的68%。移植后第二年起，移植肾失功率稳定（每年6%），主要原因是慢性排斥反应。共有52个移植肾发生慢性排斥反应（占总数的19%，6个月时处于风险中的移植肾的30%）。随着早期结果的改善，慢性排斥反应作为移植肾丢失原因的相对重要性日益增加。
