Feehally J, Harris K P, Bennett S E, Walls J
Lancet. 1986 Aug 30;2(8505):486-8. doi: 10.1016/s0140-6736(86)90359-4.
Five patients with chronic renal transplant rejection were subjected to dietary protein restriction (0.6 g/kg ideal body weight daily) with no change in immunosuppressive therapy. In all five patients the slope of the curve of reciprocal serum creatinine and time decreased (mean -46.0 +/- 11.8 before diet fell to -11.7 +/- 9.4; p less than 0.01). These findings support the hypothesis that non-immune mechanisms are dominant is chronic renal transplant failure.
五名患有慢性肾移植排斥反应的患者接受了饮食蛋白质限制（每日0.6克/千克理想体重），免疫抑制治疗未改变。在所有五名患者中，血清肌酐倒数与时间曲线的斜率均下降（饮食前平均为-46.0±11.8降至-11.7±9.4；p<0.01）。这些发现支持了非免疫机制在慢性肾移植失败中占主导地位的假说。
