Zhu Xiang, Yao Chenguang, Wei Yanhong, Kou Zheng, Hu Kanghong
Bing Du Xue Bao. 2015 May;31(3):287-92.
The Ebola virus belongs to the Filovirus family, which causes Ebola hemorrhagic fever (mortality, 25%-90%). An outbreak of infection by the Ebola virus is sweeping across West Africa, leading to high mortality and worldwide panic. The Ebola virus has caused a serious threat to public health, so intensive scientific studies have been carried out. Several vaccines (e.g., rVSV-ZEBOV, ChAd3-ZEBOV) have been put into clinical trials and antiviral drugs (e.g., TKM-Ebola, ZMAPP) have been administered in the emergency setting to patients infected by the Ebola virus. Here, recent advances in vaccines and drugs against the Ebola virus are reviewed.
埃博拉病毒属于丝状病毒科，可引发埃博拉出血热（死亡率为25% - 90%）。一场由埃博拉病毒引发的感染疫情正在席卷西非，导致高死亡率并引发全球恐慌。埃博拉病毒已对公共卫生构成严重威胁，因此人们开展了深入的科学研究。几种疫苗（如rVSV-ZEBOV、ChAd3-ZEBOV）已进入临床试验阶段，抗病毒药物（如TKM-埃博拉、ZMAPP）已在紧急情况下用于治疗感染埃博拉病毒的患者。在此，对针对埃博拉病毒的疫苗和药物的最新进展进行综述。
