Cianferoni Antonella, Spergel Jonathan M, Muir Amanda
a 1 Division of Allergy and Immunology, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104, USA.
b 2 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Expert Rev Gastroenterol Hepatol. 2015;9(12):1501-10. doi: 10.1586/17474124.2015.1094372. Epub 2015 Oct 15.
Eosinophilic esophagitis (EoE) is a chronic allergen-mediated inflammatory disease of the esophagus. This inflammation leads to feeding difficulties, failure to thrive and vomiting in young children, and causes food impaction and esophageal stricture in adolescents and adults. In the 20 years since EoE was first described, we have gained a great deal of knowledge regarding the genetic predisposition of disease, the inflammatory milieu associated with EoE and the long-term complications of chronic inflammation. Herein, we summarize the important breakthroughs in the field including both in vitro and in vivo analysis. We discuss insights that we have gained from large-scale unbiased genetic analysis, a multitude of genetically and chemically altered mouse models of EoE and most importantly, the results of clinical trials of various pharmacologic agents. Understanding these successes and failures may be the key to developing more effective therapeutic strategies.
嗜酸性粒细胞性食管炎（EoE）是一种由慢性变应原介导的食管炎症性疾病。这种炎症会导致幼儿出现喂养困难、生长发育迟缓及呕吐，并在青少年和成人中引发食物嵌塞和食管狭窄。自首次描述EoE以来的20年里，我们在疾病的遗传易感性、与EoE相关的炎症环境以及慢性炎症的长期并发症方面获得了大量知识。在此，我们总结该领域的重要突破，包括体外和体内分析。我们讨论从大规模无偏倚基因分析、多种EoE基因和化学改变小鼠模型中获得的见解，最重要的是，各种药物临床试验的结果。了解这些成功与失败可能是制定更有效治疗策略的关键。
