Clayton Frederic, Peterson Kathryn
Department of Pathology, The University of Utah, Huntsman Cancer Hospital, 1950 Circle of Hope, Room N3100, Salt Lake City, UT 84112, USA.
Division of Gastroenterology, The University of Utah, 30 North 1900 East SOM 4R118, Salt Lake City, UT 84132, USA.
Gastrointest Endosc Clin N Am. 2018 Jan;28(1):1-14. doi: 10.1016/j.giec.2017.07.011. Epub 2017 Oct 7.
Eosinophilic esophagitis is an adaptive immune response to patient-specific antigens, mostly foods. Eosinophilic esophagitis is not solely IgE-mediated and is likely characterized by Th2 lymphocytes with an impaired esophageal barrier function. The key cytokines and chemokines are thymic stromal lymphopoeitin, interleukin-13, CCL26/eotaxin-3, and transforming growth factor-β, all involved in eosinophil recruitment and remodeling. Chronic food dysphagia and food impactions, the feared late complications, are related in part to dense subepithelial fibrosis, likely induced by interleukin-13 and transforming growth factor-β.
嗜酸性粒细胞性食管炎是针对患者特异性抗原（主要是食物）的适应性免疫反应。嗜酸性粒细胞性食管炎并非仅由IgE介导，其特征可能是食管屏障功能受损的Th2淋巴细胞。关键的细胞因子和趋化因子包括胸腺基质淋巴细胞生成素、白细胞介素-13、CCL26/嗜酸性粒细胞趋化因子-3和转化生长因子-β，它们均参与嗜酸性粒细胞的募集和重塑。慢性食物吞咽困难和食物嵌塞是令人担忧的晚期并发症，部分与致密的上皮下纤维化有关，这可能是由白细胞介素-13和转化生长因子-β诱导的。
