James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
University of Melbourne, Department of Surgery and Olivia Newton-John Cancer Research Institute, Austin Hospital and Peter MacCallum Cancer Centre, Melbourne, Australia.
Eur Urol. 2016 Feb;69(2):191-2. doi: 10.1016/j.eururo.2015.09.045. Epub 2015 Oct 23.
Although three large randomized prospective clinical trials have demonstrated that postoperative radiotherapy in patients with adverse pathological features reduces prostate-specific antigen recurrence and may decrease clinical failure, this approach has not gained widespread acceptance, likely because the data strongly support such an approach only in men with Gleason ≥7 with positive surgical margins.
尽管三项大型随机前瞻性临床试验表明，对于具有不良病理特征的患者，术后放疗可降低前列腺特异性抗原复发率，并可能降低临床失败风险，但这种方法并未得到广泛认可，这可能是因为数据仅强烈支持对 Gleason 评分≥7 且切缘阳性的男性采用这种方法。
