FoxO1在神经干细胞分化中的功能调控
Functional regulation of FoxO1 in neural stem cell differentiation.
作者信息
Kim D-Y, Hwang I, Muller F L, Paik J-H
机构信息
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, USA.
Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
出版信息
Cell Death Differ. 2015 Dec;22(12):2034-45. doi: 10.1038/cdd.2015.123. Epub 2015 Oct 16.
Abstract
Forkhead transcription factor family O (FoxO) maintains adult stem cell reserves by supporting their long-term proliferative potential. MicroRNAs (miRs) regulate neuronal stem/progenitor cell (NSPC) proliferation and differentiation during neural development by controlling the expression of a specific set of target genes. In the neurogenic subventricular zone, FoxO1 is specifically expressed in NSPCs and is no longer detected during the transition to neuroblast stage, forming an inverse correlation with miR-9 expression. The 3'-untranslated region of FoxO1 contains a conserved target sequence of miR-9 and FoxO1 expression is coordinated in concert with miR-9 during neuronal differentiation. Our study demonstrates that FoxO1 contributes to NSPC fate decision through its cooperation with the Notch signaling pathway.
摘要
叉头转录因子O家族（FoxO）通过支持成体干细胞的长期增殖潜能来维持其储备。微小RNA（miR）在神经发育过程中通过控制一组特定靶基因的表达来调节神经干细胞/祖细胞（NSPC）的增殖和分化。在神经发生的脑室下区，FoxO1在NSPC中特异性表达，在向神经母细胞阶段转变过程中不再被检测到，与miR-9的表达呈负相关。FoxO1的3'-非翻译区包含miR-9的保守靶序列，并且在神经元分化过程中FoxO1的表达与miR-9协同调节。我们的研究表明，FoxO1通过与Notch信号通路合作来促进NSPC的命运决定。
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