Mahadevan Anand, Patel Vivek L, Dagoglu Nergiz
Oncology (Williston Park). 2015 Oct;29(10):743-51.
The initial treatment for primary and locoregional melanoma is surgery. Systemic therapy, and more recently immune therapy, has been the mainstay in the adjuvant and particularly the metastatic setting. Aside from palliation, there is a limited role for definitive radiation therapy for melanoma. However, in the adjuvant setting, postoperative radiation can improve locoregional disease control, albeit with potential toxicity and limited survival benefit. Stereotactic radiosurgery plays a vital role in the treatment of limited brain and extracranial metastasis.
原发性和局部区域性黑色素瘤的初始治疗方法是手术。全身治疗，以及最近的免疫治疗，一直是辅助治疗的主要手段，尤其是在转移性疾病的治疗中。除了姑息治疗外，确定性放射治疗在黑色素瘤治疗中的作用有限。然而，在辅助治疗中，术后放疗可以改善局部区域疾病控制，尽管存在潜在毒性且生存获益有限。立体定向放射外科在局限性脑转移和颅外转移的治疗中起着至关重要的作用。
